An Evaluation of the Xpert MTB/RIF Assay and Detection of False-positive Rifampicin Resistance in Mycobacterium Tuberculosis

Overview

Journal Diagn Microbiol Infect Dis

Specialties Infectious Diseases
Microbiology
Pathology

Date 2012 Jul 24

PMID 22819240

Citations 47

Authors

Deborah A Williamson

Indira Basu

James Bower

Joshua T Freeman

Gillian Henderson

Sally A Roberts

Affiliations

Soon will be listed here.

Abstract

Recent reports suggest that false-positive rifampicin resistance may be assigned by the Xpert MTB/RIF assay. We analysed 169 specimens using the MTB/RIF assay. Using culture as the gold standard, we found that the assay had 100% sensitivity and specificity for detecting M. tuberculosis. However, we found that the assay incorrectly assigned rifampicin resistance in 4/13 (31%) of cases.

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