Mesenchymal Stromal Cells: a Key Player in 'innate Tolerance'?

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2012 Jul 19

PMID 22804624

Citations 35

Authors

Francesco Dazzi

Luciene Lopes

Ling Weng

Affiliations

Soon will be listed here.

Abstract

The existence of a mesenchymal stromal cell (MSC) population with the main property of physically supporting parenchymal tissues has long been recognized in virtually all organs. However, it was only recently that MSC have been identified as playing a novel role in modulating inflammation. It has been extensively documented that, under particular circumstances, MSC potently impair virtually all cells of the immune system, including antigen-presenting-cells.

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