Environmental Conditioning in the Control of Macrophage Thrombospondin-1 Production

Overview

Journal Sci Rep

Specialty Science

Date 2012 Jul 18

PMID 22803005

Citations 22

Authors

Jezrom B Fordham

Jing Hua

Sarah R Morwood

Lauren P Schewitz-Bowers

David A Copland

Andrew D Dick

Lindsay B Nicholson

Affiliations

Soon will be listed here.

Abstract

Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune infiltrate. Macrophages are a source of TSP-1, which they produce in response to TLR4 mediated signals. Their production of TSP-1 is regulated by environmental signals that establish a threshold for the level of protein secretion that can be induced by LPS stimulation. Th1 and Th2 cytokines raise this threshold which leads to less TSP-1 production, while signals that promote the generation of regulatory macrophages lower it. TSP-1 plays no direct role in the regulation of its own secretion. In vivo in uveitis, in the presence of TLR-4 ligands, TSP-1 is initially produced by recruited macrophages but this decreases in the presence of inflammatory cytokines. The adaptive immune system therefore plays a dominant role in regulating TSP-1 production in the target organ during acute inflammation.

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References

Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H, Ikeda H . Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther. 2003; 100(2):171-94. DOI: 10.1016/j.pharmthera.2003.08.003. View

Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N . IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol. 2011; 12(3):231-8. DOI: 10.1038/ni.1990. View

Mosser D, Edwards J . Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008; 8(12):958-69. PMC: 2724991. DOI: 10.1038/nri2448. View

Adams J, Lawler J . The thrombospondins. Int J Biochem Cell Biol. 2004; 36(6):961-8. PMC: 2885884. DOI: 10.1016/j.biocel.2004.01.004. View

Masli S, Turpie B, Wayne Streilein J . Thrombospondin orchestrates the tolerance-promoting properties of TGFbeta-treated antigen-presenting cells. Int Immunol. 2006; 18(5):689-99. DOI: 10.1093/intimm/dxl006. View

Streit M, Velasco P, Brown L, Skobe M, Richard L, Riccardi L . Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am J Pathol. 1999; 155(2):441-52. PMC: 1866855. DOI: 10.1016/S0002-9440(10)65140-1. View

Kerr E, Copland D, Dick A, Nicholson L . The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis. Prog Retin Eye Res. 2008; 27(5):527-35. DOI: 10.1016/j.preteyeres.2008.07.001. View

Rosenbaum J, McDevitt H, Guss R, Egbert P . Endotoxin-induced uveitis in rats as a model for human disease. Nature. 1980; 286(5773):611-3. DOI: 10.1038/286611a0. View

Krakowski M, Owens T . Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol. 1996; 26(7):1641-6. DOI: 10.1002/eji.1830260735. View

10.

Calder C, Nicholson L, Dick A . A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis. J Immunol. 2005; 175(10):6286-93. DOI: 10.4049/jimmunol.175.10.6286. View

11.

Luger D, Silver P, Tang J, Cua D, Chen Z, Iwakura Y . Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008; 205(4):799-810. PMC: 2292220. DOI: 10.1084/jem.20071258. View

12.

Lawler J, Sunday M, Thibert V, Duquette M, George E, Rayburn H . Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest. 1998; 101(5):982-92. PMC: 508649. DOI: 10.1172/JCI1684. View

13.

Saban D, Bock F, Chauhan S, Masli S, Dana R . Thrombospondin-1 derived from APCs regulates their capacity for allosensitization. J Immunol. 2010; 185(8):4691-7. PMC: 3090006. DOI: 10.4049/jimmunol.1001133. View

14.

Li S, Liu Z, Uzunel M, Sundqvist K . Endogenous thrombospondin-1 is a cell-surface ligand for regulation of integrin-dependent T-lymphocyte adhesion. Blood. 2006; 108(9):3112-20. DOI: 10.1182/blood-2006-04-016832. View

15.

Hirota K, Duarte J, Veldhoen M, Hornsby E, Li Y, Cua D . Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol. 2011; 12(3):255-63. PMC: 3040235. DOI: 10.1038/ni.1993. View

16.

Zamiri P, Masli S, Kitaichi N, Taylor A, Wayne Streilein J . Thrombospondin plays a vital role in the immune privilege of the eye. Invest Ophthalmol Vis Sci. 2005; 46(3):908-19. DOI: 10.1167/iovs.04-0362. View

17.

Desmedt M, Rottiers P, Dooms H, Fiers W, Grooten J . Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses. J Immunol. 1998; 160(11):5300-8. View

18.

MUNDER P, Modolell M, HOELZL WALLACH D . Cell propagation on films of polymeric fluorocarbon as a means to regulate pericellular pH and pO(2) in cultured monolayers. FEBS Lett. 1971; 15(3):191-196. DOI: 10.1016/0014-5793(71)80309-5. View

19.

Kerr E, Raveney B, Copland D, Dick A, Nicholson L . Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. J Autoimmun. 2008; 31(4):354-61. DOI: 10.1016/j.jaut.2008.08.006. View

20.

Streit M, Velasco P, Riccardi L, Spencer L, Brown L, Janes L . Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. EMBO J. 2000; 19(13):3272-82. PMC: 313956. DOI: 10.1093/emboj/19.13.3272. View