Sphingolipid Regulation of Tissue Fibrosis

Overview

Journal Open Rheumatol J

Publisher Bentham Open

Specialty Rheumatology

Date 2012 Jul 18

PMID 22802910

Citations 31

Authors

Barry S Shea

Andrew M Tager

Affiliations

Soon will be listed here.

Abstract

Bioactive sphingolipids, such as sphingosine 1-phosphate (S1P), dihydrosphingosine 1-phosphate (dhS1P) and ceramide, regulate a diverse array of cellular processes. Many of these processes are important components of wound-healing responses to tissue injury, including cellular apoptosis, vascular leak, fibroblast migration, and TGF-β signaling. Since over-exuberant or aberrant wound-healing responses to repetitive injury have been implicated in the pathogenesis of tissue fibrosis, these signaling sphingolipids have the potential to influence the development and progression of fibrotic diseases. Here we review accumulating in vitro and in vivo data indicating that these lipid mediators can in fact influence fibrogenesis in numerous organ systems, including the lungs, skin, liver, heart, and eye. Targeting these lipids, their receptors, or the enzymes involved in their metabolism consequently now appears to hold great promise for the development of novel therapies for fibrotic diseases.

Citing Articles

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Amelioration of Fibrosis via S1P Inhibition Is Regulated by Inactivation of TGF-β and SPL Pathways in the Human Cornea.

Nicholas S, Basu S, Mandal N, Karamichos D Int J Mol Sci. 2024; 25(12).

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Ceramides in Autoimmune Rheumatic Diseases: Existing Evidence and Therapeutic Considerations for Diet as an Anticeramide Treatment.

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He X, Zhou M, Cheng C, Li S, Gao Y, Ma Z Front Pharmacol. 2022; 13:896198.

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