Solid Lipid Nanoparticles of Ondansetron HCl for Intranasal Delivery: Development, Optimization and Evaluation

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2012 Jul 18

PMID 22802103

Citations 16

Authors

Ashwini S Joshi

Hitesh S Patel

Veena S Belgamwar

Anshuman Agrawal

Avinash R Tekade

Affiliations

Soon will be listed here.

Abstract

The present investigation deals with the development and statistical optimization of solid lipid nanoparticles (SLNs) of ondansetron HCl (OND) for intranasal (i.n.) delivery. SLNs were prepared using the solvent diffusion technique and a 2(3) factorial design. The concentrations of lipid, surfactant and cosurfactant were independent variables in this design, whereas, particle size and entrapment efficiency (EE) were dependent variables. The particle size of the SLNs was found to be 320-498 nm, and the EE was between 32.89 and 56.56 %. The influence of the lipid, surfactant and cosurfactant on the particle size and EE was studied. A histological study revealed no adverse response of SLNs on sheep nasal mucosa. Transmission electron microscopic analysis showed spherical shape particles. Differential scanning calorimetry and X-ray diffraction studies indicated that the drug was completely encapsulated in a lipid matrix. In vitro drug release studies carried out in phosphate buffer (pH 6.6) indicated that the drug transport was of Fickian type. Gamma scintigraphic imaging in rabbits after i.n. administration showed rapid localization of the drug in the brain. Hence, OND SLNs is a promising nasal delivery system for rapid and direct nose-to-brain delivery.

Citing Articles

Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems.

Safarov R, Fedotova O, Uvarova A, Gordienko M, Menshutina N Pharmaceuticals (Basel). 2024; 17(9).

PMID: 39338342 PMC: 11435088. DOI: 10.3390/ph17091180.

Navigating the Nose-to-Brain Route: A Systematic Review on Lipid-Based Nanocarriers for Central Nervous System Disorders.

Agosti E, Zeppieri M, Antonietti S, Battaglia L, Ius T, Gagliano C Pharmaceutics. 2024; 16(3).

PMID: 38543223 PMC: 10975610. DOI: 10.3390/pharmaceutics16030329.

Fabrication of TPGS decorated Etravirine loaded lipidic nanocarriers as a neoteric oral bioavailability enhancer for lymphatic targeting.

Muheem A, Wasim M, Aldosari E, Baboota S, Ali J Discov Nano. 2024; 19(1):5.

PMID: 38175319 PMC: 10766915. DOI: 10.1186/s11671-023-03954-x.

A Physiologically Based Pharmacokinetic Model to Predict Systemic Ondansetron Concentration in Liver Cirrhosis Patients.

Alqahtani F, Alruwaili A, Alasmari M, Almazroa S, Alsuhaibani K, Rasool M Pharmaceuticals (Basel). 2023; 16(12).

PMID: 38139819 PMC: 10747545. DOI: 10.3390/ph16121693.

Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety.

Mahmoud K, Elhesaisy N, Rashed A, Mikhael E, Fadl M, Elsadek M Sci Rep. 2023; 13(1):510.

PMID: 36627363 PMC: 9831377. DOI: 10.1038/s41598-023-27665-6.

References

Zhang N, Ping Q, Huang G, Xu W, Cheng Y, Han X . Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int J Pharm. 2006; 327(1-2):153-9. DOI: 10.1016/j.ijpharm.2006.07.026. View

Zhang J, Fan Y, Smith E . Experimental design for the optimization of lipid nanoparticles. J Pharm Sci. 2008; 98(5):1813-9. DOI: 10.1002/jps.21549. View

Hu F, Hong Y, Yuan H . Preparation and characterization of solid lipid nanoparticles containing peptide. Int J Pharm. 2004; 273(1-2):29-35. DOI: 10.1016/j.ijpharm.2003.12.016. View

Kaur I, Bhandari R, Bhandari S, Kakkar V . Potential of solid lipid nanoparticles in brain targeting. J Control Release. 2008; 127(2):97-109. DOI: 10.1016/j.jconrel.2007.12.018. View

Singh S, Dobhal A, Jain A, Pandit J, Chakraborty S . Formulation and evaluation of solid lipid nanoparticles of a water soluble drug: Zidovudine. Chem Pharm Bull (Tokyo). 2010; 58(5):650-5. DOI: 10.1248/cpb.58.650. View

Vyas T, Babbar A, Sharma R, Singh S, Misra A . Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. J Pharm Sci. 2006; 95(3):570-80. DOI: 10.1002/jps.20480. View

Patil S, Sawant K . Development, optimization and in vitro evaluation of alginate mucoadhesive microspheres of carvedilol for nasal delivery. J Microencapsul. 2008; 26(5):432-43. DOI: 10.1080/02652040802456726. View

Hu F, Yuan H, Zhang H, Fang M . Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int J Pharm. 2002; 239(1-2):121-8. DOI: 10.1016/s0378-5173(02)00081-9. View

Muller R, Jacobs C . Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability. Int J Pharm. 2002; 237(1-2):151-61. DOI: 10.1016/s0378-5173(02)00040-6. View

10.

Mehnert W, Mader K . Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2001; 47(2-3):165-96. DOI: 10.1016/s0169-409x(01)00105-3. View

11.

Trotta M, Debernardi F, Caputo O . Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int J Pharm. 2003; 257(1-2):153-60. DOI: 10.1016/s0378-5173(03)00135-2. View

12.

Mahajan H, Gattani S . Nasal administration of ondansetron using a novel microspheres delivery system. Pharm Dev Technol. 2009; 14(2):226-32. DOI: 10.1080/10837450802585286. View

13.

Kumar M, Misra A, Babbar A, Mishra A, Mishra P, Pathak K . Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm. 2008; 358(1-2):285-91. DOI: 10.1016/j.ijpharm.2008.03.029. View

14.

Gasco M . Lipid nanoparticles: perspectives and challenges. Adv Drug Deliv Rev. 2007; 59(6):377-8. DOI: 10.1016/j.addr.2007.05.004. View

15.

Varshosaz J, Ghaffari S, Khoshayand M, Atyabi F, Azarmi S, Kobarfard F . Development and optimization of solid lipid nanoparticles of amikacin by central composite design. J Liposome Res. 2009; 20(2):97-104. DOI: 10.3109/08982100903103904. View

16.

Jain S, Chauk D, Mahajan H, Tekade A, Gattani S . Formulation and evaluation of nasal mucoadhesive microspheres of sumatriptan succinate. J Microencapsul. 2009; 26(8):711-21. DOI: 10.3109/02652040802685241. View

17.

Pople P, Singh K . Development and evaluation of topical formulation containing solid lipid nanoparticles of vitamin A. AAPS PharmSciTech. 2007; 7(4):91. PMC: 2750328. DOI: 10.1208/pt070491. View