Comparison of the Tuberculin Skin Test and Interferon-γ Release Assay for the Diagnosis of Latent Tuberculosis Infection Before Kidney Transplantation

Overview

Journal Infection

Date 2012 Jul 18

PMID 22802098

Citations 12

Authors

S Y Kim

G S Jung

S K Kim

J Chang

M S Kim

Y S Kim

Y A Kang

D J Joo

Affiliations

Soon will be listed here.

Abstract

Purpose: The evaluation of latent tuberculosis infection (LTBI) is recommended before kidney transplantation. The interferon-γ release assay has been reported to be more specific than the tuberculin skin test (TST) for detecting LTBI. We compared the TST and QuantiFERON-TB Gold In-Tube test (QFT-GIT) for the screening for LTBI and determined the agreement between the two tests in renal transplant recipients before transplantation.

Methods: Adult patients who were evaluated for renal transplantation between May 2010 and February 2012 at Severance Hospital in South Korea were prospectively enrolled. We performed TST and QFT-GIT.

Results: Of the 126 patients, 23 (19.3 %) had positive TST results and 53 (42.1 %) had positive QFT-GIT results. Agreement between the TST and QFT-GIT was fair (κ = 0.26, P < 0.001). The induration size of TST was significantly correlated with a positive rate of QFT-GIT (P = 0.015). Age (odds ratio [OR] 1.08, 95 % confidence interval [CI] 1.03-1.13, P = 0.003), male sex (OR 2.73, 95 % CI 1.17-6.38, P = 0.021), and risk for LTBI (OR 4.62, 95 % CI 1.15-18.64, P = 0.031) were significantly associated with positive QFT-GIT results. For positive TST results, only male sex was associated (OR 4.29, 95 % CI 1.40-13.20, P = 0.011).

Conclusion: The positivity for QFT-GIT was higher than the positivity for TST, and QFT-GIT more accurately reflected the risk for LTBI. However, a further longitudinal study is needed in order to confirm that the QFT-GIT test can truly predict the development of TB after renal transplantation.

Citing Articles

Screening for Latent Tuberculosis Infection in Solid Organ Transplant Recipients to Predict Active Disease: A Systematic Review and Meta-Analysis of Diagnostic Studies.

Yahav D, Gitman M, Margalit I, Avni T, Leeflang M, Husain S Open Forum Infect Dis. 2023; 10(8):ofad324.

PMID: 37559757 PMC: 10407303. DOI: 10.1093/ofid/ofad324.

Mycobacterial infections in solid organ transplant recipients.

Rashid H, Begum N, Kashem T Korean J Transplant. 2022; 35(4):208-217.

PMID: 35769848 PMC: 9235462. DOI: 10.4285/kjt.21.0033.

Update of the mechanism and characteristics of tuberculosis in chronic kidney disease : Review article.

Zhang X, Chen P, Xu G Wien Klin Wochenschr. 2022; 134(13-14):501-510.

PMID: 35254535 DOI: 10.1007/s00508-022-02009-y.

Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients.

Bandiara R, Indrasari A, Dewi Rengganis A, Sukesi L, Afiatin A, Santoso P J Clin Tuberc Other Mycobact Dis. 2022; 27:100302.

PMID: 35243009 PMC: 8886030. DOI: 10.1016/j.jctube.2022.100302.

Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates.

Samavat S, Alahyari S, Sangian A, Nasiri M, Nafar M, Firoozan A J Res Med Sci. 2021; 26:88.

PMID: 34899926 PMC: 8607175. DOI: 10.4103/jrms.JRMS_708_20.

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