Novel Pathways in the Pathobiology of Human Abdominal Aortic Aneurysms

Overview

Journal Pathobiology

Specialties Cell Biology
Pathology

Date 2012 Jul 17

PMID 22797469

Citations 26

Authors

Irene Hinterseher

Robert Erdman

James R Elmore

Elizabeth Stahl

Matthew C Pahl

Kimberly Derr

Alicia Golden

John H Lillvis

Matthew C Cindric

Kathryn Jackson

William D Bowen

Charles M Schworer

Michael A Chernousov

David P Franklin

John L Gray

Robert P Garvin

Zoran Gatalica

David J Carey

Gerard Tromp

Helena Kuivaniemi

Affiliations

Soon will be listed here.

Abstract

Objectives: Abdominal aortic aneurysm (AAA), a dilatation of the infrarenal aorta, typically affects males >65 years. The pathobiological mechanisms of human AAA are poorly understood. The goal of this study was to identify novel pathways involved in the development of AAAs.

Methods: A custom-designed 'AAA-chip' was used to assay 43 of the differentially expressed genes identified in a previously published microarray study between AAA (n = 15) and control (n = 15) infrarenal abdominal aorta. Protein analyses were performed on selected genes.

Results: Altogether 38 of the 43 genes on the 'AAA-chip' showed significantly different expression. Novel validated genes in AAA pathobiology included ADCY7, ARL4C, BLNK, FOSB, GATM, LYZ, MFGE8, PRUNE2, PTPRC, SMTN, TMODI and TPM2. These genes represent a wide range of biological functions, such as calcium signaling, development and differentiation, as well as cell adhesion not previously implicated in AAA pathobiology. Protein analyses for GATM, CD4, CXCR4, BLNK, PLEK, LYZ, FOSB, DUSP6, ITGA5 and PTPRC confirmed the mRNA findings.

Conclusion: The results provide new directions for future research into AAA pathogenesis to study the role of novel genes confirmed here. New treatments and diagnostic tools for AAA could potentially be identified by studying these novel pathways.

Citing Articles

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