Studies on Cardiotonic Agents. II. Synthesis of Novel Phthalazine and 1,2,3-benzotriazine Derivatives

Overview

Journal Chem Pharm Bull (Tokyo)

Specialties Chemistry
Pharmacology

Date 1990 Aug 1

PMID 2279280

Citations 5

Authors

Y Nomoto

H Obase

H Takai

M Teranishi

J Nakamura

K Kubo

Affiliations

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Abstract

A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.

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