Oxidative Damage, Inflammation, and Toll-like Receptor 4 Pathway Are Increased in Preeclamptic Patients: a Case-control Study

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2012 Jul 14

PMID 22792416

Citations 17

Authors

Fabiana C B Bernardi

Francine Felisberto

Francieli Vuolo

Fabricia Petronilho

Daniela R Souza

Thais F Luciano

Claudio T De Souza

Cristiane Ritter

Felipe Dal-Pizzol

Affiliations

Soon will be listed here.

Abstract

Problem: There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients.

Method Of Study: 33 PE patients and 33 normotensive pregnant women were included. The maternal section of the placenta and blood were collected to the determination of oxidative damage markers (thiobarbituric acid reactive species and protein carbonyls), inflammatory response (interleukin-6 and myeloperoxidase activity), and activation of the TLR-4-NF-kB pathway.

Results: An increase of IL-6 levels in both plasma and placenta was observed, but myeloperoxidase activity was not significantly different comparing the groups. Oxidative damage parameters were increased in plasma and placenta in PE patients. A significant increase of the protein levels of TLR-4 and NF-kB was observed in the placenta.

Conclusion: The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage.

Citing Articles

Pharmacologic and endotoxic reprogramming of renal vasodilatory, inflammatory, and apoptotic blemishes in weaning preeclamptic rats.

Morgaan H, Sallam M, El-Deeb N, El-Gowelli H, El-Gowilly S, El-Mas M Sci Rep. 2025; 15(1):8137.

PMID: 40057533 PMC: 11890745. DOI: 10.1038/s41598-025-87586-4.

Analysis of the evolution of placental oxidative stress research from a bibliometric perspective.

Chen A, Tian M, Luo Z, Cao X, Gu Y Front Pharmacol. 2024; 15:1475244.

PMID: 39484166 PMC: 11524950. DOI: 10.3389/fphar.2024.1475244.

Longitudinal Assessment of Oxidative Stress Markers in Women with Preeclampsia.

Godhamgaonkar A, Dangat K, Randhir K, Chhetri S, Shelke K, Shukla D Reprod Sci. 2024; 31(9):2731-2740.

PMID: 38700823 DOI: 10.1007/s43032-024-01574-z.

Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds.

Jimenez-Osorio A, Carreon-Torres E, Correa-Solis E, Angel-Garcia J, Arias-Rico J, Jimenez-Garza O Antioxidants (Basel). 2023; 12(10).

PMID: 37891973 PMC: 10604737. DOI: 10.3390/antiox12101894.

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies.

Vilotic A, Nacka-Aleksic M, Pirkovic A, Bojic-Trbojevic Z, Dekanski D, Jovanovic Krivokuca M Int J Mol Sci. 2022; 23(23).

PMID: 36498901 PMC: 9738067. DOI: 10.3390/ijms232314574.

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