Co-detection in the Pathogenesis of Severe Hand-foot-mouth Disease

Overview

Journal Arch Virol

Specialty Microbiology

Date 2012 Jul 14

PMID 22791110

Citations 7

Authors

Li-Juan Liu

Hong-Mei Xu

Xiu-Jun Li

Jun Wang

Xian-Jun Wang

Shu-Jun Ding

Fang Tang

Jing Wang

Ying-Jie Zhang

Affiliations

Soon will be listed here.

Abstract

It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.

Citing Articles

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Molecular epidemiology of human enterovirus 71 at the origin of an epidemic of fatal hand, foot and mouth disease cases in Cambodia.

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Co-circulation and genomic recombination of coxsackievirus A16 and enterovirus 71 during a large outbreak of hand, foot, and mouth disease in Central China.

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References

Wang S, Liu C, Tseng H, Wang J, Huang C, Chen Y . Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications. Clin Infect Dis. 1999; 29(1):184-90. DOI: 10.1086/520149. View

Wang S, Liu C . Enterovirus 71: epidemiology, pathogenesis and management. Expert Rev Anti Infect Ther. 2009; 7(6):735-42. DOI: 10.1586/eri.09.45. View

Stals A, Baert L, Botteldoorn N, Werbrouck H, Herman L, Uyttendaele M . Multiplex real-time RT-PCR for simultaneous detection of GI/GII noroviruses and murine norovirus 1. J Virol Methods. 2009; 161(2):247-53. DOI: 10.1016/j.jviromet.2009.06.019. View

Qu X, Duan Z, Qi Z, Xie Z, Gao H, Liu W . Human bocavirus infection, People's Republic of China. Emerg Infect Dis. 2007; 13(1):165-8. PMC: 2725817. DOI: 10.3201/eid1301.060842. View

Shiihara T, Watanabe M, Honma A, Kato M, Morita Y, Ichiyama T . Rotavirus associated acute encephalitis/encephalopathy and concurrent cerebellitis: report of two cases. Brain Dev. 2007; 29(10):670-3. DOI: 10.1016/j.braindev.2007.04.005. View

Ooi M, Wong S, Podin Y, Akin W, del Sel S, Mohan A . Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin Infect Dis. 2007; 44(5):646-56. DOI: 10.1086/511073. View

. Deaths among children during an outbreak of hand, foot, and mouth disease--Taiwan, Republic of China, April-July 1998. MMWR Morb Mortal Wkly Rep. 1998; 47(30):629-32. View

Huang C, Liu C, Chang Y, Chen C, Wang S, Yeh T . Neurologic complications in children with enterovirus 71 infection. N Engl J Med. 1999; 341(13):936-42. DOI: 10.1056/NEJM199909233411302. View

Goldwater P, Rowland K, Thesinger M, Abbott K, Grieve A, Palombo E . Rotavirus encephalopathy: pathogenesis reviewed. J Paediatr Child Health. 2001; 37(2):206-9. DOI: 10.1046/j.1440-1754.2001.00596.x. View

10.

Yan J, Wang J, Liu C, Yang H, Su I . An outbreak of enterovirus 71 infection in Taiwan 1998: a comprehensive pathological, virological, and molecular study on a case of fulminant encephalitis. J Clin Virol. 2000; 17(1):13-22. DOI: 10.1016/s1386-6532(00)00067-6. View

11.

Ito S, Takeshita S, Nezu A, Aihara Y, Usuku S, Noguchi Y . Norovirus-associated encephalopathy. Pediatr Infect Dis J. 2006; 25(7):651-2. DOI: 10.1097/01.inf.0000225789.92512.6d. View

12.

Hamaguchi T, Fujisawa H, Sakai K, Okino S, Kurosaki N, Nishimura Y . Acute encephalitis caused by intrafamilial transmission of enterovirus 71 in adult. Emerg Infect Dis. 2008; 14(5):828-30. PMC: 2600258. DOI: 10.3201/eid1405.071121. View

13.

Liu C, Tseng H, Wang S, Wang J, Su I . An outbreak of enterovirus 71 infection in Taiwan, 1998: epidemiologic and clinical manifestations. J Clin Virol. 2000; 17(1):23-30. DOI: 10.1016/s1386-6532(00)00068-8. View

14.

Ho M, CHEN E, Hsu K, Twu S, Chen K, Tsai S . An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med. 1999; 341(13):929-35. DOI: 10.1056/NEJM199909233411301. View

15.

Skrondal A . Interaction as departure from additivity in case-control studies: a cautionary note. Am J Epidemiol. 2003; 158(3):251-8. DOI: 10.1093/aje/kwg113. View

16.

Obinata K, Okumura A, Nakazawa T, Kamata A, Niizuma T, Kinoshita K . Norovirus encephalopathy in a previously healthy child. Pediatr Infect Dis J. 2010; 29(11):1057-9. DOI: 10.1097/INF.0b013e3181e78889. View

17.

Chang L, Huang L, Gau S, Wu Y, Hsia S, Fan T . Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med. 2007; 356(12):1226-34. DOI: 10.1056/NEJMoa065954. View

18.

Perez-Velez C, Anderson M, Robinson C, McFarland E, Nix W, Pallansch M . Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge. Clin Infect Dis. 2007; 45(8):950-7. DOI: 10.1086/521895. View

19.

Kobayashi S, Negishi Y, Ando N, Ito T, Nakano M, Togari H . Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms. Eur J Pediatr. 2010; 169(10):1287-91. DOI: 10.1007/s00431-010-1202-y. View