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Association Between KCNQ1 Genetic Variants and Obesity in Chinese Patients with Type 2 Diabetes

Overview
Journal Diabetologia
Specialty Endocrinology
Date 2012 Jul 14
PMID 22790062
Citations 14
Authors
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Abstract

Aims/hypothesis: There is evidence of overlap between susceptibility loci for type 2 diabetes and obesity. The aim of this study is to explore the association between the established type 2 diabetes locus KCNQ1 and obesity in Han Chinese.

Methods: We recruited 6,667 and 6,606 diabetic case-control samples from Shanghai and Hong Kong, respectively. Of the samples, 7.5% and 6.3% were excluded because of genotyping failure or data missing in the association analyses of rs2237892 and rs2237895 with obesity/BMI, respectively.

Results: We found that rs2237892 was associated with lower BMI and lower incidence of overweight/obesity in diabetic patients from Hong Kong (BMI, β = -0.0060 per diabetes risk C allele for log(10)BMI [95% CI -0.0088, -0.0032; p = 2.83 × 10(-5)]; overweight/obesity, OR 0.880 for C allele [95% CI 0.807, 0.960; p = 0.004]) and in the meta-analysis of cases from the two regions (BMI, combined β = -0.0048 per C allele for log(10)BMI [95% CI -0.0070, -0.0026; p = 2.20 × 10(-5)]; overweight/obesity, combined OR 0.890 for C allele [95% CI 0.830, 0.955; p = 0.001]). rs2237895 was also related to decreased BMI (combined β = -0.0042 per diabetes risk C allele for log(10)BMI [95% CI -0.0062, -0.0022; p = 4.30 × 10(-5)]). A significant association with waist circumference was detected for rs2237892 in the pooled analyses (β = -0.0026 per C allele for log(10)[waist circumference] [95% CI -0.0045, -0.0007; p = 0.007]). However, neither an association with the risk of being overweight or obese nor associations with quantitive traits were detected for rs2237892 or rs2237895 in controls.

Conclusion: Our findings indicate that KCNQ1 is associated with obesity in Chinese patients with type 2 diabetes.

Citing Articles

Effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus: An updated meta-analysis.

Jiang H, Du H, Deng Y, Liang X Diabetol Metab Syndr. 2021; 13(1):75.

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Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China.

Wang X, Wu J, Wu Y, Wang M, Wang Z, Wu T J Diabetes Res. 2020; 2020:8278574.

PMID: 32016123 PMC: 6982365. DOI: 10.1155/2020/8278574.


Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors.

Witka B, Oktaviani D, Marcellino M, Barliana M, Abdulah R Diabetes Metab Syndr Obes. 2020; 12:2689-2706.

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Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon Islands.

Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R PLoS One. 2017; 12(3):e0172676.

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Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes.

Li Q, Tang T, Jiang F, Zhang R, Chen M, Yin J Acta Pharmacol Sin. 2016; 38(1):80-89.

PMID: 27694910 PMC: 5220536. DOI: 10.1038/aps.2016.103.


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