Cancer and Inflammation: an Aspirin a Day Keeps the Cancer at Bay

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2012 Jul 14

PMID 22789999

Citations 7

Authors

Marina Mione

Leonard I Zon

Affiliations

Soon will be listed here.

Abstract

Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE(2) promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE(2) production and could be used with other anti-tumor agents in the treatment of cancer.

Citing Articles

PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation.

Yang J, Wang J, Liu Y, Zhang Y, Huang W, Zou Y Cell Death Dis. 2021; 12(7):707.

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A novel zebrafish intestinal tumor model reveals a role for -dependent tumor-liver crosstalk in causing adverse effects on the host.

Enya S, Kawakami K, Suzuki Y, Kawaoka S Dis Model Mech. 2018; 11(8).

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A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity.

Tan J, Li C, Wang Q, Li S, Chen S, Zhang J Mol Pharm. 2018; 15(4):1724-1728.

PMID: 29522683 PMC: 7057395. DOI: 10.1021/acs.molpharmaceut.8b00070.

Advances in genomics of bony fish.

Spaink H, Jansen H, Dirks R Brief Funct Genomics. 2013; 13(2):144-56.

PMID: 24291769 PMC: 3954040. DOI: 10.1093/bfgp/elt046.

Aspirin and its related non-steroidal anti-inflammatory drugs.

Mahdi E Libyan J Med. 2013; 8(1):21569.

PMID: 23819926 PMC: 3699782. DOI: 10.3402/ljm.v8i0.21569.

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