Biologically Based Strategies to Augment Rotator Cuff Tears

Overview

Journal Int J Shoulder Surg

Date 2012 Jul 13

PMID 22787334

Citations 10

Authors

M Schaer

M Schober

S Berger

P Boileau

M A Zumstein

Affiliations

Soon will be listed here.

Abstract

Lesions of the rotator cuff (RC) are among the most frequent tendon injuries. In spite of the developments in both open and arthroscopic surgery, RC repair still very often fails. In order to reduce the failure rate after surgery, several experimental in vitro and in vivo therapy methods have been developed for biological improvement of the reinsertion. This article provides an overview of the current evidence for augmentation of RC reconstruction with growth factors. Furthermore, potential future therapeutic approaches are discussed. We performed a comprehensive search of the PubMed database using various combinations of the keywords "tendon," "rotator cuff," "augmentation," "growth factor," "platelet-rich fibrin," and "platelet-rich plasma" for publications up to 2011. Given the linguistic capabilities of the research team, we considered publications in English, German, French, and Spanish. We excluded literature reviews, case reports, and letters to the editor.

Citing Articles

Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine.

Lal L P M, Agrawal D J Orthop Sports Med. 2024; 6(2):67-72.

PMID: 38784690 PMC: 11113011. DOI: 10.26502/josm.511500144.

Association of Preoperative Vitamin D Deficiency With Retear Rate and Early Pain After Arthroscopic Rotator Cuff Repair: A Retrospective Cohort Study.

Chen J, Lou J, Wang W, Xu G Orthop J Sports Med. 2022; 10(10):23259671221130315.

PMID: 36276423 PMC: 9580096. DOI: 10.1177/23259671221130315.

Clinical outcomes and structural integrity rate of arthroscopic augmented rotator cuff repairs using extracellular porcine matrix patch.

Consigliere P, Bernasconi A, Dimock R, Narvani A Shoulder Elbow. 2022; 14(1 Suppl):38-51.

PMID: 35845616 PMC: 9284254. DOI: 10.1177/1758573220982607.

Enhancement of Rotator Cuff Healing with Farnesol-Impregnated Gellan Gum/Hyaluronic Acid Hydrogel Membranes in a Rabbit Model.

Lin Y, Lee S, Lin F, Wu G, Wu C, Kuo S Pharmaceutics. 2021; 13(7).

PMID: 34202556 PMC: 8309098. DOI: 10.3390/pharmaceutics13070944.

Effectiveness of Biologic Factors in Shoulder Disorders.

Giotis D, Aryaei A, Vasilakakos T, Paschos N Open Orthop J. 2017; 11:163-182.

PMID: 28400884 PMC: 5366381. DOI: 10.2174/1874325001711010163.

References

Zumstein M, Jost B, Hempel J, Hodler J, Gerber C . The clinical and structural long-term results of open repair of massive tears of the rotator cuff. J Bone Joint Surg Am. 2008; 90(11):2423-31. DOI: 10.2106/JBJS.G.00677. View

Sher J, Uribe J, Posada A, Murphy B, Zlatkin M . Abnormal findings on magnetic resonance images of asymptomatic shoulders. J Bone Joint Surg Am. 1995; 77(1):10-5. DOI: 10.2106/00004623-199501000-00002. View

Uhthoff H, Seki M, Backman D, Trudel G, Himori K, Sano H . Tensile strength of the supraspinatus after reimplantation into a bony trough: an experimental study in rabbits. J Shoulder Elbow Surg. 2002; 11(5):504-9. DOI: 10.1067/mse.2002.126760. View

Seeherman H, Archambault J, Rodeo S, Turner A, Zekas L, DAugusta D . rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model. J Bone Joint Surg Am. 2008; 90(10):2206-19. DOI: 10.2106/JBJS.G.00742. View

Hirose K, Kondo S, Choi H, Mishima S, Iwata H, Ishiguro N . Spontaneous healing process of a supraspinatus tendon tear in rabbits. Arch Orthop Trauma Surg. 2004; 124(6):374-7. DOI: 10.1007/s00402-004-0663-8. View

Bensaid W, Triffitt J, Blanchat C, Oudina K, Sedel L, Petite H . A biodegradable fibrin scaffold for mesenchymal stem cell transplantation. Biomaterials. 2003; 24(14):2497-502. DOI: 10.1016/s0142-9612(02)00618-x. View

Derwin K, Baker A, Spragg R, Leigh D, Iannotti J . Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties. J Bone Joint Surg Am. 2006; 88(12):2665-72. DOI: 10.2106/JBJS.E.01307. View

Neer 2nd C . Impingement lesions. Clin Orthop Relat Res. 1983; (173):70-7. View

Bedi A, Fox A, Kovacevic D, Deng X, Warren R, Rodeo S . Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair. Am J Sports Med. 2009; 38(2):308-17. DOI: 10.1177/0363546509347366. View

10.

Thomopoulos S, Zampiakis E, Das R, Silva M, Gelberman R . The effect of muscle loading on flexor tendon-to-bone healing in a canine model. J Orthop Res. 2008; 26(12):1611-7. PMC: 2601721. DOI: 10.1002/jor.20689. View

11.

Choi H, Kondo S, Hirose K, Ishiguro N, Hasegawa Y, Iwata H . Expression and enzymatic activity of MMP-2 during healing process of the acute supraspinatus tendon tear in rabbits. J Orthop Res. 2002; 20(5):927-33. DOI: 10.1016/S0736-0266(02)00016-5. View

12.

Lo I, Marchuk L, Hollinshead R, Hart D, Frank C . Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons. Am J Sports Med. 2004; 32(5):1223-9. DOI: 10.1177/0363546503262200. View

13.

Yoshikawa T, Tohyama H, Katsura T, Kondo E, Kotani Y, Matsumoto H . Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep. Am J Sports Med. 2006; 34(12):1918-25. DOI: 10.1177/0363546506294469. View

14.

Schmutz S, Fuchs T, Regenfelder F, Steinmann P, Zumstein M, Fuchs B . Expression of atrophy mRNA relates to tendon tear size in supraspinatus muscle. Clin Orthop Relat Res. 2008; 467(2):457-64. PMC: 2628494. DOI: 10.1007/s11999-008-0565-0. View

15.

Dohan Ehrenfest D, Del Corso M, Diss A, Mouhyi J, Charrier J . Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol. 2010; 81(4):546-55. DOI: 10.1902/jop.2009.090531. View

16.

Chan B, Fu S, Qin L, Rolf C, Chan K . Supplementation-time dependence of growth factors in promoting tendon healing. Clin Orthop Relat Res. 2006; 448:240-7. DOI: 10.1097/01.blo.0000205875.97468.e4. View

17.

Uggen C, Dines J, McGarry M, Grande D, Lee T, Limpisvasti O . The effect of recombinant human platelet-derived growth factor BB-coated sutures on rotator cuff healing in a sheep model. Arthroscopy. 2010; 26(11):1456-62. DOI: 10.1016/j.arthro.2010.02.025. View

18.

Gulotta L, Kovacevic D, Packer J, Deng X, Rodeo S . Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model. Am J Sports Med. 2011; 39(6):1282-9. DOI: 10.1177/0363546510395485. View

19.

Soslowsky L, Thomopoulos S, Esmail A, Flanagan C, Iannotti J, Williamson 3rd J . Rotator cuff tendinosis in an animal model: role of extrinsic and overuse factors. Ann Biomed Eng. 2002; 30(8):1057-63. DOI: 10.1114/1.1509765. View

20.

Ide J, Kikukawa K, Hirose J, Iyama K, Sakamoto H, Fujimoto T . The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon. J Shoulder Elbow Surg. 2009; 18(3):391-8. DOI: 10.1016/j.jse.2009.01.013. View