Low Energy Electron Stimulated Desorption from DNA Films Dosed with Oxygen

Overview

Journal J Chem Phys

Publisher American Institute of Physics

Specialties Biophysics
Chemistry

Date 2012 Jul 12

PMID 22779623

Citations 5

Authors

Nasrin Mirsaleh-Kohan

Andrew D Bass

Pierre Cloutier

Sylvain Massey

Leon Sanche

Affiliations

Soon will be listed here.

Abstract

Desorption of anions stimulated by 1-18 eV electron impact on self-assembled monolayer (SAM) films of single DNA strands is measured as a function of film temperature (50-250 K). The SAMs, composed of 10 nucleotides, are dosed with O(2). The OH(-) desorption yields increase markedly with exposure to O(2) at 50 K and are further enhanced upon heating. In contrast, the desorption yields of O(-), attributable to dissociative electron attachment to trapped O(2) molecules decrease with heating. Irradiation of the DNA films prior to the deposition of O(2) shows that this surprising increase in OH(-) desorption, at elevated temperatures, arises from the reaction of O(2) with damaged DNA sites. These results thus appear to be a manifestation of the so-called "oxygen fixation" effect, well known in radiobiology.

Citing Articles

Oxygen Effect on 0-30 eV Electron Damage to DNA Under Different Hydration Levels: Base and Clustered Lesions, Strand Breaks and Crosslinks.

Gao Y, Wang X, Cloutier P, Zheng Y, Sanche L Molecules. 2025; 29(24.

PMID: 39770123 PMC: 11680046. DOI: 10.3390/molecules29246033.

Low-Energy Electron Damage to Condensed-Phase DNA and Its Constituents.

Gao Y, Zheng Y, Sanche L Int J Mol Sci. 2021; 22(15).

PMID: 34360644 PMC: 8345953. DOI: 10.3390/ijms22157879.

The Role of Humidity and Oxygen Level on Damage to DNA Induced by Soft X-rays and Low-Energy Electrons.

Alizadeh E, Sanche L J Phys Chem C Nanomater Interfaces. 2014; 117(43):22445-22453.

PMID: 24976877 PMC: 4072655. DOI: 10.1021/jp403350j.

Note: transient negative ions as initiators of oxygen fixation in <20 eV electron-irradiated DNA.

Massey S, Bass A, Sanche L J Chem Phys. 2013; 139(18):186101.

PMID: 24320304 PMC: 4623751. DOI: 10.1063/1.4829770.

Dissociative electron attachment to DNA-diamine thin films: impact of the DNA close environment on the OH- and O- decay channels.

Boulanouar O, Fromm M, Mavon C, Cloutier P, Sanche L J Chem Phys. 2013; 139(5):055101.

PMID: 23927286 PMC: 3813476. DOI: 10.1063/1.4815967.

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