» Articles » PMID: 22778420

Enhancement of Dendritic Cell Activation Via CD40 Ligand-expressing γδ T Cells is Responsible for Protective Immunity to Plasmodium Parasites

Overview
Specialty Science
Date 2012 Jul 11
PMID 22778420
Citations 26
Authors
Affiliations
Soon will be listed here.
Abstract

Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected γδ T-cell-deficient (TCRδ-KO) mice and control wild-type mice with Plasmodium berghei XAT, which is a nonlethal strain. Although infected red blood cells were eliminated within 30 d after infection, TCRδ-KO mice could not clear the infected red blood cells, showed high parasitemia, and eventually died. Therefore, γδ T cells are essential for clearance of the parasites. Here, we found that γδ T cells play a key role in dendritic cell activation after Plasmodium infection. On day 5 postinfection, γδ T cells produced IFN-γ and expressed CD40 ligand during dendritic cell activation. These results suggest that γδ T cells enhance dendritic cell activation via IFN-γ and CD40 ligand-CD40 signaling. This hypothesis is supported strongly by the fact that in vivo induction of CD40 signaling prevented the death of TCRδ-KO mice after infection with P. berghei XAT. This study improves our understanding of protective immunity against malaria and provides insights into γδ T-cell-mediated protective immunity against various infectious diseases.

Citing Articles

γδ T cell-mediated activation of cDC1 orchestrates CD4 Th1 cell priming in malaria.

Ibraheem Y, Bayarsaikhan G, Macalinao M, Kimura K, Yui K, Aoshi T Front Immunol. 2024; 15:1426316.

PMID: 39211036 PMC: 11357926. DOI: 10.3389/fimmu.2024.1426316.


A landscape review of malaria vaccine candidates in the pipeline.

Tajudeen Y, Oladipo H, Yusuff S, Abimbola S, Abdulkadir M, Oladunjoye I Trop Dis Travel Med Vaccines. 2024; 10(1):19.

PMID: 39085983 PMC: 11293096. DOI: 10.1186/s40794-024-00222-3.


An IFNγ-dependent immune-endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response.

Sestan M, Mikasinovic S, Benic A, Wueest S, Dimitropoulos C, Mladenic K Nat Immunol. 2024; 25(6):981-993.

PMID: 38811816 DOI: 10.1038/s41590-024-01848-3.


The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.

Harit K, Bhattacharjee R, Matuschewski K, Becker J, Kalinke U, Schluter D Cell Death Dis. 2023; 14(7):480.

PMID: 37516734 PMC: 10387084. DOI: 10.1038/s41419-023-06014-5.


Properties and Roles of γδT Cells in NSM Infected C57BL/6 Mice.

Xie H, Xie S, Wang M, Wei H, Huang H, Xie A Front Cell Infect Microbiol. 2022; 11:788546.

PMID: 35127555 PMC: 8811364. DOI: 10.3389/fcimb.2021.788546.


References
1.
Schulz O, Edwards A, Schito M, Aliberti J, Manickasingham S, Sher A . CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity. 2000; 13(4):453-62. DOI: 10.1016/s1074-7613(00)00045-5. View

2.
Wykes M, Liu X, Beattie L, Stanisic D, Stacey K, Smyth M . Plasmodium strain determines dendritic cell function essential for survival from malaria. PLoS Pathog. 2007; 3(7):e96. PMC: 1904473. DOI: 10.1371/journal.ppat.0030096. View

3.
Nakazawa S, Brown A, Maeno Y, Smith C, Aikawa M . Malaria-induced increase of splenic gamma delta T cells in humans, monkeys, and mice. Exp Parasitol. 1994; 79(3):391-8. DOI: 10.1006/expr.1994.1101. View

4.
van der Heyde H, Manning D, Weidanz W . Role of CD4+ T cells in the expansion of the CD4-, CD8- gamma delta T cell subset in the spleens of mice during blood-stage malaria. J Immunol. 1993; 151(11):6311-7. View

5.
van der Heyde H, Elloso M, Chang W, Kaplan M, Manning D, Weidanz W . Gamma delta T cells function in cell-mediated immunity to acute blood-stage Plasmodium chabaudi adami malaria. J Immunol. 1995; 154(8):3985-90. View