Mucosal Antibodies in the Regulation of Tolerance and Allergy to Foods

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2012 Jul 11

PMID 22777546

Citations 21

Authors

M Cecilia Berin

Affiliations

Soon will be listed here.

Abstract

The intestinal mucosa is densely packed with antibody-secreting B cells, the majority of which produce IgA. Mucosal antibodies have traditionally been thought of as neutralizing antibodies that exclude antigens, but they also function in antigen sampling, allowing for selective transcytosis of antigens from the intestinal lumen. IgE-mediated antigen uptake can facilitate the development of allergic reactions to foods, but emerging evidence indicates that IgG-mediated antigen uptake may also play an important role in the development of immune tolerance to foods, particularly in the neonate. This review will focus on the role of intestinal immunoglobulins in the development of clinical tolerance and allergy to food antigens.

Citing Articles

Viral infections in celiac disease: what should be considered for better management.

Asri N, Mohammadi S, Jahdkaran M, Rostami-Nejad M, Rezaei-Tavirani M, Mohebbi S Clin Exp Med. 2024; 25(1):25.

PMID: 39731690 PMC: 11682017. DOI: 10.1007/s10238-024-01542-6.

Antibodies in breast milk: Pro-bodies designed for healthy newborn development.

Verhasselt V, Tellier J, Carsetti R, Tepekule B Immunol Rev. 2024; 328(1):192-204.

PMID: 39435770 PMC: 11659933. DOI: 10.1111/imr.13411.

Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model.

Wang R, Patel D, Goruk S, Richard C, Field C J Nutr. 2024; 154(12):3790-3802.

PMID: 39401683 PMC: 11662241. DOI: 10.1016/j.tjnut.2024.10.021.

Saliva antibody profiles are associated with reaction threshold and severity of peanut allergic reactions.

Ho H, Arditi Z, Radigan L, Grishina G, Zhang L, Chun Y J Allergy Clin Immunol. 2024; 154(3):690-697.e4.

PMID: 38821318 PMC: 11380589. DOI: 10.1016/j.jaci.2024.05.020.

Metabolic fitness of IgA plasma cells in the gut requires DOCK8.

Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M Mucosal Immunol. 2023; 17(3):431-449.

PMID: 38159726 PMC: 11571232. DOI: 10.1016/j.mucimm.2023.12.001.

References

Belut D, Moneret-Vautrin D, Nicolas J, GRILLIAT J . IgE levels in intestinal juice. Dig Dis Sci. 1980; 25(5):323-32. DOI: 10.1007/BF01308055. View

Yu L, Yang P, Berin M, Di Leo V, Conrad D, McKay D . Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4. Gastroenterology. 2001; 121(2):370-81. DOI: 10.1053/gast.2001.26470. View

Johansen F, Pekna M, Norderhaug I, Haneberg B, Hietala M, Krajci P . Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J Exp Med. 1999; 190(7):915-22. PMC: 2195652. DOI: 10.1084/jem.190.7.915. View

Brandtzaeg P, Baklien K . Inconclusive immunohistochemistry of human IgE in mucosal pathology. Lancet. 1976; 1(7972):1297-8. DOI: 10.1016/s0140-6736(76)91767-0. View

Spiekermann G, Finn P, Ward E, Dumont J, Dickinson B, Blumberg R . Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med. 2002; 196(3):303-10. PMC: 2193935. DOI: 10.1084/jem.20020400. View

Husby S, Oxelius V, Teisner B, Jensenius J, Svehag S . Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. Int Arch Allergy Appl Immunol. 1985; 77(4):416-22. DOI: 10.1159/000233819. View

Kaiserlian D, Lachaux A, Grosjean I, Graber P, Bonnefoy J . Intestinal epithelial cells express the CD23/Fc epsilon RII molecule: enhanced expression in enteropathies. Immunology. 1993; 80(1):90-5. PMC: 1422110. View

Nakajima S, Gillespie D, Gleich G . Differences between IgA and IgE as secretory proteins. Clin Exp Immunol. 1975; 21(2):306-17. PMC: 1538262. View

Hadis U, Wahl B, Schulz O, Hardtke-Wolenski M, Schippers A, Wagner N . Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity. 2011; 34(2):237-46. DOI: 10.1016/j.immuni.2011.01.016. View

10.

Kunkel E, Butcher E . Plasma-cell homing. Nat Rev Immunol. 2003; 3(10):822-9. DOI: 10.1038/nri1203. View

11.

Favre L, Spertini F, Corthesy B . Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses. J Immunol. 2005; 175(5):2793-800. DOI: 10.4049/jimmunol.175.5.2793. View

12.

Negrao-Correa D, Adams L, Bell R . Intestinal transport and catabolism of IgE: a major blood-independent pathway of IgE dissemination during a Trichinella spiralis infection of rats. J Immunol. 1996; 157(9):4037-44. View

13.

Bitonti A, Dumont J, Low S, Peters R, Kropp K, Palombella V . Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci U S A. 2004; 101(26):9763-8. PMC: 470748. DOI: 10.1073/pnas.0403235101. View

14.

Mantis N, Cheung M, Chintalacharuvu K, Rey J, Corthesy B, Neutra M . Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. J Immunol. 2002; 169(4):1844-51. DOI: 10.4049/jimmunol.169.4.1844. View

15.

Verhasselt V, Milcent V, Cazareth J, Kanda A, Fleury S, Dombrowicz D . Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med. 2008; 14(2):170-5. DOI: 10.1038/nm1718. View

16.

Rodrigo Mora J, Iwata M, Eksteen B, Song S, Junt T, Senman B . Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006; 314(5802):1157-60. DOI: 10.1126/science.1132742. View

17.

Yen E, Hornick J, Dehlink E, Dokter M, Baker A, Fiebiger E . Comparative analysis of FcεRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010; 51(5):584-92. PMC: 2965300. DOI: 10.1097/MPG.0b013e3181de7685. View

18.

Qiao S, Kobayashi K, Johansen F, Sollid L, Andersen J, Milford E . Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A. 2008; 105(27):9337-42. PMC: 2453734. DOI: 10.1073/pnas.0801717105. View

19.

Matson A, Thrall R, Rafti E, Lingenheld E, Puddington L . IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring. Clin Mol Allergy. 2010; 8:9. PMC: 2914046. DOI: 10.1186/1476-7961-8-9. View

20.

Lopez-Exposito I, Song Y, Jarvinen K, Srivastava K, Li X . Maternal peanut exposure during pregnancy and lactation reduces peanut allergy risk in offspring. J Allergy Clin Immunol. 2009; 124(5):1039-46. PMC: 2801422. DOI: 10.1016/j.jaci.2009.08.024. View