Lysophospholipid Acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From Discovery to Disease

Overview

Journal Curr Opin Lipidol

Specialty Biochemistry

Date 2012 Jul 11

PMID 22777291

Citations 34

Authors

Anil K Agarwal

Affiliations

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Abstract

Purpose Of Review: Over the past several years, many more isoforms for the same enzymes, specifically for 1-acylglycerol-3-phosphate O-acyltransferases (AGPATs), have been cloned and studied. In this review, we summarize their biochemical features and discuss their functional role.

Recent Findings: The most significant role of these AGPATs appeared from our observation of AGPAT2 in the biology of adipose tissue (adipocytes) in humans and mice. Other isoforms are shown to be implicated in lung, reproductive and cardiac muscle function and in the cause of cancer. In-vitro substrate specificities of these AGPATs also suggest the in-vivo role of these AGPATs in remodeling of several of the glycerophospholipids.

Summary: Despite significant progress in understanding the role of these AGPATs, much is still to be discovered in terms of how each of these AGPATs function in the presence or absence of other AGPATs and what their functional role might be.

Citing Articles

Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases.

Korbecki J, Bosiacki M, Pilarczyk M, Gassowska-Dobrowolska M, Jarmuzek P, Szucko-Kociuba I Cancers (Basel). 2024; 16(11).

PMID: 38893234 PMC: 11171337. DOI: 10.3390/cancers16112115.

Regulated regeneration of adipose tissue in lipodystrophic -null mice partially ameliorates hepatic steatosis.

Agarwal A, Tunison K, Horton J, Garg A iScience. 2024; 27(4):109517.

PMID: 38623324 PMC: 11016861. DOI: 10.1016/j.isci.2024.109517.

Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction.

Agarwal A, Tunison K, Vale G, McDonald J, Li X, Horton J iScience. 2024; 27(1):108653.

PMID: 38274405 PMC: 10809107. DOI: 10.1016/j.isci.2023.108653.

A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome.

Malik M, Saqib M, Mientjes E, Acharya A, Alam M, Wallaard I Eur J Hum Genet. 2023; 31(12):1447-1454.

PMID: 37821758 PMC: 10689475. DOI: 10.1038/s41431-023-01475-w.

Regulated adipose tissue-specific expression of human in lipodystrophic -null mice results in regeneration of adipose tissue.

Agarwal A, Tunison K, Vale G, McDonald J, Li X, Scherer P iScience. 2023; 26(10):107806.

PMID: 37752957 PMC: 10518674. DOI: 10.1016/j.isci.2023.107806.