Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum Vulgare Ssp. Siculum

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2012 Jul 11

PMID 22777187

Citations 18

Authors

Sergio Rosselli

Maurizio Bruno

Francesco Maria Raimondo

Vivienne Spadaro

Mehmet Varol

Ayse Tansu Koparal

Antonella Maggio

Affiliations

Soon will be listed here.

Abstract

A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.

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