Proinflammatory Effects of C-Peptide in Different Tissues

Overview

Journal Int J Inflam

Publisher Wiley

Date 2012 Jul 5

PMID 22762010

Citations 8

Authors

Dusica Vasic

Daniel Walcher

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is well known as an inflammatory disease that can lead to clinical complications such as heart attack or stroke. C-peptide as a cleavage product of proinsulin is in the last few decades known as an active peptide with a number of different effects on microvascular and macrovascular complications in type 2 diabetic patients. Patients with insulin resistance and early type 2 diabetes show elevated levels of C-peptide in blood. Several last findings demonstrated deposition of C-peptide in the vessel wall in ApoE-deficient mice and induction of local inflammation. Besides that, C-peptide has proliferative effects on human mesangial cells. This review discusses recently published proinflammatory effects of C-peptide in different tissues.

Citing Articles

Urinary c-peptide creatinine ratio (UCPCR) as a predictor of coronary artery disease in type 1 diabetes mellitus.

Irilouzadian R, Afaghi S, Esmaeili Tarki F, Rahimi F, Malekpour Alamadari N Endocrinol Diabetes Metab. 2023; 6(3):e413.

PMID: 36808709 PMC: 10164436. DOI: 10.1002/edm2.413.

Higher fasting C-peptide is associated with post-stroke depression: a multicenter prospective cohort study.

Wang Y, Sun W, Miao J, Qiu X, Lan Y, Pan C BMC Neurol. 2021; 21(1):383.

PMID: 34607565 PMC: 8489065. DOI: 10.1186/s12883-021-02413-3.

Effect of C-peptide Alone or in Combination with Nicotinamide on Insulin Levels from Pancreatic Islets in Mouse.

Ahangarpour A, Ali Akbari F, Fathi Moghadam H Malays J Med Sci. 2016; 23(1):15-21.

PMID: 27540321 PMC: 4975584.

ProInflam: a webserver for the prediction of proinflammatory antigenicity of peptides and proteins.

Gupta S, Madhu M, Sharma A, Sharma V J Transl Med. 2016; 14(1):178.

PMID: 27301453 PMC: 4908730. DOI: 10.1186/s12967-016-0928-3.

C-Peptide Is Independently Associated with an Increased Risk of Coronary Artery Disease in T2DM Subjects: A Cross-Sectional Study.

Wang L, Lin P, Ma A, Zheng H, Wang K, Li W PLoS One. 2015; 10(6):e0127112.

PMID: 26098780 PMC: 4476669. DOI: 10.1371/journal.pone.0127112.

References

Al-Rasheed N, Chana R, Baines R, Willars G, Brunskill N . Ligand-independent activation of peroxisome proliferator-activated receptor-gamma by insulin and C-peptide in kidney proximal tubular cells: dependent on phosphatidylinositol 3-kinase activity. J Biol Chem. 2004; 279(48):49747-54. DOI: 10.1074/jbc.M408268200. View

Ohtomo Y, Bergman T, Johansson B, Jornvall H, Wahren J . Differential effects of proinsulin C-peptide fragments on Na+, K+-ATPase activity of renal tubule segments. Diabetologia. 1998; 41(3):287-91. DOI: 10.1007/s001250050905. View

Zhong Z, Kotova O, Davidescu A, Ehren I, Ekberg K, Jornvall H . C-peptide stimulates Na+, K+-ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells. Cell Mol Life Sci. 2004; 61(21):2782-90. DOI: 10.1007/s00018-004-4258-x. View

Suzuki L, Poot M, Gerrity R, Bornfeldt K . Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels. Diabetes. 2001; 50(4):851-60. DOI: 10.2337/diabetes.50.4.851. View

STARY H, Chandler A, Dinsmore R, Fuster V, Glagov S, INSULL Jr W . A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol. 1995; 15(9):1512-31. DOI: 10.1161/01.atv.15.9.1512. View

Kitamura T, Kimura K, Jung B, Makondo K, Sakane N, Yoshida T . Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem J. 2002; 366(Pt 3):737-44. PMC: 1222821. DOI: 10.1042/BJ20020344. View

Wahren J, Ekberg K, Johansson J, Henriksson M, Pramanik A, Johansson B . Role of C-peptide in human physiology. Am J Physiol Endocrinol Metab. 2000; 278(5):E759-68. DOI: 10.1152/ajpendo.2000.278.5.E759. View

Mavrakanas T, Frachebois C, Soualah A, Aloui F, Julier I, Bastide D . C-peptide and chronic complications in patients with type-2 diabetes and the metabolic syndrome. Presse Med. 2009; 38(10):1399-403. DOI: 10.1016/j.lpm.2009.02.023. View

Zhong Z, Davidescu A, Ehren I, Ekberg K, Jornvall H, Wahren J . C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells. Diabetologia. 2004; 48(1):187-97. DOI: 10.1007/s00125-004-1602-5. View

10.

Munte C, Vilela L, Kalbitzer H, Charles Garratt R . Solution structure of human proinsulin C-peptide. FEBS J. 2005; 272(16):4284-93. DOI: 10.1111/j.1742-4658.2005.04843.x. View

11.

Inukai T, Matsutomo R, Tayama K, Aso Y, Takemura Y . Relation between the serum level of C-peptide and risk factors for coronary heart disease and diabetic microangiopathy in patients with type-2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 1999; 107(1):40-5. DOI: 10.1055/s-0029-1212071. View

12.

Harbour J, Dean D . Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol. 2000; 2(4):E65-7. DOI: 10.1038/35008695. View

13.

Kitamura T, Kimura K, Makondo K, Furuya D, Suzuki M, Yoshida T . Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats. Diabetologia. 2003; 46(12):1698-705. DOI: 10.1007/s00125-003-1232-3. View

14.

Zhang Y, Yasumoto Y, Ikeda T, Takenouchi S, Sogabe A, Nosaki T . Apolipoprotein E regulates primary cultured human mesangial cell proliferation. Nephron Exp Nephrol. 2005; 102(2):e62-70. DOI: 10.1159/000088402. View

15.

Wen M, Segerer S, Dantas M, Brown P, Hudkins K, Goodpaster T . Renal injury in apolipoprotein E-deficient mice. Lab Invest. 2002; 82(8):999-1006. DOI: 10.1097/01.lab.0000022222.03120.d4. View

16.

Karalliedde J, Viberti G . Proteinuria in diabetes: bystander or pathway to cardiorenal disease?. J Am Soc Nephrol. 2010; 21(12):2020-7. DOI: 10.1681/ASN.2010030250. View

17.

Ghiselli G, Schaefer E, Gascon P, Breser Jr H . Type III hyperlipoproteinemia associated with apolipoprotein E deficiency. Science. 1981; 214(4526):1239-41. DOI: 10.1126/science.6795720. View

18.

Walcher D, Babiak C, Poletek P, Rosenkranz S, Bach H, Betz S . C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2. Circ Res. 2006; 99(11):1181-7. DOI: 10.1161/01.RES.0000251231.16993.88. View

19.

Scalia R, Coyle K, Levine B, Booth G, Lefer A . C-peptide inhibits leukocyte-endothelium interaction in the microcirculation during acute endothelial dysfunction. FASEB J. 2000; 14(14):2357-64. DOI: 10.1096/fj.00-0183com. View

20.

Joshua I, Zhang Q, Falcone J, Bratcher A, Rodriguez W, Tyagi S . Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus: role of insulin and C-peptide. J Cell Biochem. 2005; 96(6):1149-56. DOI: 10.1002/jcb.20620. View