Tetradian Oscillation of Estrogen Receptor α is Necessary to Prevent Liver Lipid Deposition

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2012 Jul 5

PMID 22761311

Citations 52

Authors

Alessandro Villa

Sara Della Torre

Alessia Stell

Jennifer Cook

Myles Brown

Adriana Maggi

Affiliations

Soon will be listed here.

Abstract

In the liver of female mice, the transcriptional activity of estrogen receptor (ER) α oscillates in phase with the 4-d-long estrous cycle. Here systemic, genome-wide analysis demonstrates that ER tetradian oscillation is necessary to generate pulses of expression in genes for fatty acid and cholesterol synthesis. This ER-dependent metabolic programming changes with pregnancy and after cessation of ovarian function due to age or surgical menopause, suggesting that ER signaling is optimized to coordinate liver functions with the energetic requirements of each reproductive stage. Alterations of amplitude and frequency of the tetradian cycle, as observed after surgical menopause, age, or specific ablation of the hepatic Igf-1 gene, are associated with liver fat deposition. Appropriate hormone replacement therapy reinstating the oscillatory activity of liver ER prevents the effect of surgical menopause on fat deposition in liver.

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