Auraptene and Its Effects on the Re-emergence of Colon Cancer Stem Cells

Overview

Journal Phytother Res

Publisher Wiley

Date 2012 Jul 5

PMID 22761031

Citations 11

Authors

Francesco Epifano

Salvatore Genovese

Rebecca Miller

Adhip P N Majumdar

Affiliations

Soon will be listed here.

Abstract

Recent studies indicate that auraptene (7-geranyloxycoumarin, AUR), a geranyloxycoumarin extracted from fruits of edible plants belonging to the Rutaceae family, may represent a novel lead compound for dietary colon cancer chemoprevention in rodents. As a continuation of studies aimed to better depict the pharmacological effects and mechanism of action of the title natural compound, the current investigation was undertaken to determine whether AUR would be able to prevent the growth and sphere (surrogate tumors) formation of FOLFOX-resistant colon cancer cells that are highly enriched in cancer stem cells (CSCs). Our results demonstrate that AUR at a concentration of 10 μM was able to inhibit the growth and formation of colonospheres of FOLFOX-resistant colon cancer HT-29 cells in vitro. The corresponding parental cells were also similarly affected by AUR at the same concentration level. The reduction in the growth and colonospheres formation in FOLFOX-resistant HT-29 was also associated with a concomitant decrease in phospho-epidermal growth factor receptor. These findings suggest that AUR could prevent the re-emergence of CSCs.

Citing Articles

The Emerging Role of Natural Products in Cancer Treatment.

Ghosh S, Kumar Das S, Sinha K, Ghosh B, Sen K, Ghosh N Arch Toxicol. 2024; 98(8):2353-2391.

PMID: 38795134 DOI: 10.1007/s00204-024-03786-3.

Joining up the scattered anticancer knowledge on auraptene and umbelliprenin: a meta-analysis.

Shakiba M, Rassouli F Sci Rep. 2024; 14(1):11770.

PMID: 38783034 PMC: 11116445. DOI: 10.1038/s41598-024-62747-z.

7-Geranyloxcycoumarin enhances radio sensitivity in human prostate cancer cells.

Abolhassani Y, Mirzaei S, Nejabat M, Talebian S, Gholamhosseinian H, Iranshahi M Mol Biol Rep. 2023; 50(7):5709-5717.

PMID: 37217617 DOI: 10.1007/s11033-023-08439-9.

Protection of Mitochondrial Potential and Activity by Oxyprenylated Phenylpropanoids.

Epifano F, Genovese S, Palumbo L, Collevecchio C, Fiorito S Antioxidants (Basel). 2023; 12(2).

PMID: 36829818 PMC: 9952183. DOI: 10.3390/antiox12020259.

Combination of auraptene and arsenic trioxide induces apoptosis and cellular accumulation in the subG1 phase in adult T-cell leukemia cells.

Kazemi M, Kouhpeikar H, Delbari Z, Khodadadi F, Gerayli S, Iranshahi M Iran J Basic Med Sci. 2022; 24(12):1643-1649.

PMID: 35432798 PMC: 8976908. DOI: 10.22038/IJBMS.2021.58633.13025.

References

Horst D, Kriegl L, Engel J, Kirchner T, Jung A . Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer. Cancer Invest. 2009; 27(8):844-50. DOI: 10.1080/07357900902744502. View

Bonnet D, Dick J . Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997; 3(7):730-7. DOI: 10.1038/nm0797-730. View

Wu S, Feng B, Li K, Zhu X, Liang S, Liu X . Fish consumption and colorectal cancer risk in humans: a systematic review and meta-analysis. Am J Med. 2012; 125(6):551-9.e5. DOI: 10.1016/j.amjmed.2012.01.022. View

Mollica A, Stefanucci A, Feliciani F, Cacciatore I, Cornacchia C, Pinnen F . Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer. Curr Drug Deliv. 2012; 9(2):122-31. DOI: 10.2174/156720112800234558. View

Genovese S, Epifano F . Auraptene: a natural biologically active compound with multiple targets. Curr Drug Targets. 2010; 12(3):381-6. DOI: 10.2174/138945011794815248. View

Tanaka T, de Azevedo M, Duran N, Alderete J, Epifano F, Genovese S . Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4'-geranyloxyferulic acid. Int J Cancer. 2009; 126(4):830-40. DOI: 10.1002/ijc.24833. View

Yu Y, Kanwar S, Patel B, Nautiyal J, Sarkar F, Majumdar A . Elimination of Colon Cancer Stem-Like Cells by the Combination of Curcumin and FOLFOX. Transl Oncol. 2009; 2(4):321-8. PMC: 2781082. DOI: 10.1593/tlo.09193. View

Pietras A . Cancer stem cells in tumor heterogeneity. Adv Cancer Res. 2011; 112:255-81. DOI: 10.1016/B978-0-12-387688-1.00009-0. View

Nautiyal J, Du J, Yu Y, Kanwar S, Levi E, Majumdar A . EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine. Am J Physiol Gastrointest Liver Physiol. 2012; 302(7):G655-63. PMC: 3330776. DOI: 10.1152/ajpgi.00323.2011. View

10.

Takahashi N, Senda M, Lin S, Goto T, Yano M, Sasaki T . Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice. Mol Nutr Food Res. 2011; 55(12):1791-7. DOI: 10.1002/mnfr.201100401. View

11.

Botchkina G . Colon cancer stem cells--from basic to clinical application. Cancer Lett. 2012; 338(1):127-40. DOI: 10.1016/j.canlet.2012.04.006. View

12.

Gunn E, Williams J, Huynh D, Iannotti M, Han C, Barrios F . The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma. Leuk Lymphoma. 2011; 52(6):1085-97. DOI: 10.3109/10428194.2011.555891. View

13.

Magkou C, Nakopoulou L, Zoubouli C, Karali K, Theohari I, Bakarakos P . Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas. Breast Cancer Res. 2008; 10(3):R49. PMC: 2481499. DOI: 10.1186/bcr2103. View