Normal and Pathological Gait: What We Learn from Parkinson's Disease

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 2012 Jul 4

PMID 22752693

Citations 63

Authors

David Grabli

Carine Karachi

Marie-Laure Welter

Brian Lau

Etienne C Hirsch

Marie Vidailhet

Chantal Francois

Affiliations

Soon will be listed here.

Abstract

Gait and balance disorders represent a major therapeutic challenge in Parkinson's disease (PD). These symptoms respond poorly to dopaminergic treatments, except in the early phase of the disease. Currently, no other treatment is particularly efficient and rehabilitation appears to be the most effective approach. Since these gait and balance deficits are resistant to dopaminergic drugs, their occurrence could be related to the development of extradopaminergic lesions in PD patients. We provide a comprehensive description of the clinical features of gait and balance disorders in PD. We also highlight the brain networks involved in gait and balance control in animals and humans with a particular focus on the relevant structures in the context of PD, such as the mesencephalic locomotor region. We also review other neuronal systems that may be involved in the physiopathology of gait and balance disorders in PD (noradrenergic and serotoninergic systems, cerebellum and cortex). In addition, we review recent evidence regarding functional neurosurgery for gait disorders in PD and propose new directions for future therapeutic research.

Citing Articles

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Unraveling the stride: exploring the influence of neurogenic orthostatic hypotension on gait and balance in Parkinson's disease.

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EFFECTS OF TREADMILL GAIT TRAINING ON BALANCE IN PARKINSON'S PATIENTS AFTER DEEP BRAIN STIMULATION.

de Andrade V, Castilho Alonso A, Luna N, Rogatto F, Brech G, Bocalini D Acta Ortop Bras. 2024; 32(3):e266917.

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Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study.

Carli G, Kanel P, Roytman S, Pongmala C, Albin R, Raffel D Eur J Nucl Med Mol Imaging. 2024; 51(13):3978-3989.

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Scientometric Research and Critical Analysis of Gait and Balance in Older Adults.

Mao Q, Zheng W, Shi M, Yang F Sensors (Basel). 2024; 24(10).

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