Genome-wide Association Study in Han Chinese Identifies Four New Susceptibility Loci for Coronary Artery Disease

Overview

Journal Nat Genet

Specialty Genetics

Date 2012 Jul 4

PMID 22751097

Citations 171

Authors

Xiangfeng Lu

Laiyuan Wang

Shufeng Chen

Lin He

Xueli Yang

Yongyong Shi

Jing Cheng

Liang Zhang

C Charles Gu

Jianfeng Huang

Tangchun Wu

Yitong Ma

Jianxin Li

Jie Cao

Jichun Chen

Dongliang Ge

Zhongjie Fan

Ying Li

Liancheng Zhao

Hongfan Li

Xiaoyang Zhou

Lanying Chen

Donghua Liu

Jingping Chen

Xiufang Duan

Yongchen Hao

Ligui Wang

Fanghong Lu

Zhendong Liu

Cailiang Yao

Chong Shen

Xiaodong Pu

Lin Yu

Xianghua Fang

LiHua Xu

Jianjun Mu

Xianping Wu

Runping Zheng

Naqiong Wu

Qi Zhao

Yun Li

Xiaoli Liu

Mengqin Wang

Dahai Yu

Dongsheng Hu

Xu Ji

Dongshuang Guo

Dongling Sun

Qianqian Wang

Ying Yang

Fangchao Liu

Qunxia Mao

Xiaohua Liang

Jingfeng Ji

Panpan Chen

Xingbo Mo

Dianjiang Li

Guoping Chai

Yida Tang

Xiangdong Li

Zhenhan Du

Xuehui Liu

Chenlong Dou

Zili Yang

Qingjie Meng

Dong Wang

Renping Wang

Jun Yang

Heribert Schunkert

Nilesh J Samani

Sekar Kathiresan

Muredach P Reilly

Jeanette Erdmann

Xiaozhong Peng

Xigui Wu

Depei Liu

Yuejin Yang

Runsheng Chen

Boqin Qiang

Dongfeng Gu

Affiliations

Soon will be listed here.

Abstract

We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

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