When Are Fetuses and Young Children Most Susceptible to Soil Metal Concentrations of Arsenic, Lead and Mercury?

Overview

Journal Spat Spatiotemporal Epidemiol

Publisher Elsevier

Specialty Public Health

Date 2012 Jul 4

PMID 22749212

Citations 7

Authors

Suzanne McDermott

Weichao Bao

C Marjorie Aelion

Bo Cai

Andrew Lawson

Affiliations

Soon will be listed here.

Abstract

This study was designed to analyze when, during pregnancy and early childhood, the association between soil metal concentrations of arsenic (As), lead (Pb) and mercury (Hg) and the outcome of intellectual disability (ID) is statistically significant. Using cluster analysis, we identified ten areas of land that contained a cluster of ID and areas of average risk for ID. We analyzed soil for As, Pb, and Hg and estimated the soil metal concentration at the residential sites where the woman and children lived during pregnancy and early childhood using a Bayesian Kriging model. Arsenic concentrations were associated with ID during the first trimester of pregnancy and Hg was associated with ID early in pregnancy and the first two years of childhood. The covariates that remained in the final models were also temporally associated with ID.

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