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Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (aminolevulinic Acid)

Overview
Journal Neurosurg Clin N Am
Specialty Neurosurgery
Date 2012 Jul 4
PMID 22748650
Citations 27
Authors
David W Roberts
Pablo A Valdes
Brent T Harris
Alexander Hartov
Xiaoyao Fan
Songbai Ji
Frederic Leblond
Tor D Tosteson
Brian C Wilson
Keith D Paulsen
Affiliations
Soon will be listed here.
Abstract

5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence can be used to identify tissue for resection using an adapted operating microscope. A multi-institutional clinical trial comparing fluorescence-guided versus white light tumor resection reported significant improvement in completeness of resection and 6-month progression-free survival. The degree of 5-ALA-induced fluorescence correlates with histopathologic grade of tumor, degree of tumor cell infiltration, and proliferation indices. Quantitative methodologies for assessment of tissue fluorescence have significantly improved the ability to detect tumor tissue and intraoperative diagnostic performance. These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development.

Citing Articles

Fluorescence-Guided Surgical Techniques in Adult Diffuse Low-Grade Gliomas: State-of-the-Art and Emerging Techniques: A Systematic Review.

Picart T, Gautheron A, Caredda C, Ray C, Mahieu-Williame L, Montcel B Cancers (Basel). 2024; 16(15).

PMID: 39123426 PMC: 11311317. DOI: 10.3390/cancers16152698.

Recurrent Glioblastoma-Molecular Underpinnings and Evolving Treatment Paradigms.

Chang C, Chavarro V, Gerstl J, Blitz S, Spanehl L, Dubinski D Int J Mol Sci. 2024; 25(12).

PMID: 38928445 PMC: 11203521. DOI: 10.3390/ijms25126733.

Impact of Levetiracetam Treatment on 5-Aminolevulinic Acid Fluorescence Expression in IDH1 Wild-Type Glioblastoma.

Wach J, Guresir A, Hamed M, Vatter H, Herrlinger U, Guresir E Cancers (Basel). 2022; 14(9).

PMID: 35565263 PMC: 9099986. DOI: 10.3390/cancers14092134.

Analysis of Factors Affecting 5-ALA Fluorescence Intensity in Visualizing Glial Tumor Cells-Literature Review.

Mazurek M, Szczepanek D, Orzylowska A, Rola R Int J Mol Sci. 2022; 23(2).

PMID: 35055109 PMC: 8779265. DOI: 10.3390/ijms23020926.

Characteristics of Fluorescent Intraoperative Dyes Helpful in Gross Total Resection of High-Grade Gliomas-A Systematic Review.

Mazurek M, Kulesza B, Stoma F, Osuchowski J, Mandziuk S, Rola R Diagnostics (Basel). 2020; 10(12).

PMID: 33339439 PMC: 7766001. DOI: 10.3390/diagnostics10121100.

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