RNA Interference Pathways in Fungi: Mechanisms and Functions

Overview

Journal Annu Rev Microbiol

Publisher Annual Reviews

Specialty Microbiology

Date 2012 Jul 4

PMID 22746336

Citations 114

Authors

Shwu-Shin Chang

Zhenyu Zhang

Yi Liu

Affiliations

Soon will be listed here.

Abstract

RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses small noncoding RNAs to mediate posttranscriptional/transcriptional gene silencing. The fission yeast Schizosaccharomyces pombe and the filamentous fungus Neurospora crassa have served as important model systems for RNAi research. Studies on these two organisms and other fungi have contributed significantly to our understanding of the mechanisms and functions of RNAi in eukaryotes. In addition, surprisingly diverse RNAi-mediated processes and small RNA biogenesis pathways have been discovered in fungi. In this review, we give an overview of different fungal RNAi pathways with a focus on their mechanisms and functions.

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