» Articles » PMID: 22745914

Biomechanics of Disc Degeneration

Overview
Journal Adv Orthop
Publisher Wiley
Specialty Orthopedics
Date 2012 Jun 30
PMID 22745914
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

Disc degeneration and associated disorders are among the most debated topics in the orthopedic literature over the past few decades. These may be attributed to interrelated mechanical, biochemical, and environmental factors. The treatment options vary from conservative approaches to surgery, depending on the severity of degeneration and response to conservative therapies. Spinal fusion is considered to be the "gold standard" in surgical methods till date. However, the association of adjacent level degeneration has led to the evolution of motion preservation technologies like spinal arthroplasty and posterior dynamic stabilization systems. These new technologies are aimed to address pain and preserve motion while maintaining a proper load sharing among various spinal elements. This paper provides an elaborative biomechanical review of the technologies aimed to address the disc degeneration and reiterates the point that biomechanical efficacy followed by long-term clinical success will allow these nonfusion technologies as alternatives to fusion, at least in certain patient population.

Citing Articles

Radiographic outcomes and subsidence rate in hyperlordotic versus standard lordotic interbody spacers in patients undergoing anterior cervical discectomy and fusion.

Narayanan R, Pohl N, Dalton J, Lee Y, Tomlak A, Labarbiera A J Craniovertebr Junction Spine. 2025; 15(4):475-481.

PMID: 40061183 PMC: 11888038. DOI: 10.4103/jcvjs.jcvjs_116_24.


Biomechanical Study of Symmetric Bending and Lifting Behavior in Weightlifter with Lumbar L4-L5 Disc Herniation and Physiological Straightening Using Finite Element Simulation.

Zhang C, Song Y, Zhang Q, Teo E, Liu W Bioengineering (Basel). 2024; 11(8).

PMID: 39199783 PMC: 11351717. DOI: 10.3390/bioengineering11080825.


Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units.

Singh N, Singh N, Verma R, Diwan A Bioengineering (Basel). 2024; 11(4).

PMID: 38671766 PMC: 11048157. DOI: 10.3390/bioengineering11040344.


Degenerative Thoracic Myelopathy: A Scoping Review of Epidemiology, Genetics, and Pathogenesis.

Rujeedawa T, Mowforth O, Davies B, Yang C, Nouri A, Francis J Global Spine J. 2023; 14(5):1664-1677.

PMID: 38146739 PMC: 11394495. DOI: 10.1177/21925682231224768.


Kinematics of the Cervical Spine Under Healthy and Degenerative Conditions: A Systematic Review.

Lindenmann S, Tsagkaris C, Farshad M, Widmer J Ann Biomed Eng. 2022; 50(12):1705-1733.

PMID: 36496482 PMC: 9794546. DOI: 10.1007/s10439-022-03088-8.


References
1.
Anderson P, Rouleau J . Intervertebral disc arthroplasty. Spine (Phila Pa 1976). 2004; 29(23):2779-86. DOI: 10.1097/01.brs.0000146460.11591.8a. View

2.
Crow W, Willis D . Estimating cost of care for patients with acute low back pain: a retrospective review of patient records. J Am Osteopath Assoc. 2009; 109(4):229-33. View

3.
Schnake K, Putzier M, Haas N, Kandziora F . Mechanical concepts for disc regeneration. Eur Spine J. 2006; 15 Suppl 3:S354-60. PMC: 2335380. DOI: 10.1007/s00586-006-0176-y. View

4.
Pfirrmann C, Metzdorf A, Zanetti M, Hodler J, Boos N . Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001; 26(17):1873-8. DOI: 10.1097/00007632-200109010-00011. View

5.
Oxland T, Hoffer Z, Nydegger T, Rathonyi G, Nolte L . A comparative biomechanical investigation of anterior lumbar interbody cages: central and bilateral approaches. J Bone Joint Surg Am. 2000; 82(3):383-93. View