NFKB1-94ATTG Ins/del Polymorphism (rs28362491) is Associated with Cardiovascular Disease in Patients with Rheumatoid Arthritis

Overview

Journal Atherosclerosis

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2012 Jun 30

PMID 22742859

Citations 40

Authors

Raquel Lopez-Mejias

Mercedes Garcia-Bermudez

Carlos Gonzalez-Juanatey

Santos Castaneda

Jose A Miranda-Filloy

Carmen Gomez-Vaquero

Benjamin Fernandez-Gutierrez

Alejandro Balsa

Dora Pascual-Salcedo

Ricardo Blanco

Isidoro Gonzalez-Alvaro

Javier Llorca

Javier Martin

Miguel A Gonzalez-Gay

Affiliations

Soon will be listed here.

Abstract

Introduction: Rheumatoid arthritis (RA) is an inflammatory disease associated with increased cardiovascular (CV) mortality. A recent study has disclosed association between NFKB1-94ATTG ins/del polymorphism and higher risk of coronary heart disease in healthy Caucasians. Because of that, we assessed the influence of this polymorphism in the risk of CV disease in RA patients.

Material And Methods: 1437 Spanish patients with RA were genotyped for the NFKB1-94ATTG ins/del polymorphism. Two hundred and seventy-one of them (18.8%) had experienced CV events.

Results: After adjusting for sex, age at RA diagnosis and traditional CV risk factors RA patients carrying the NFKB1 del/del genotype had higher risk of CV events than those with ins/ins genotype (Hazard ratio [HR] = 1.76, 95% CI: 1.05-2.97, p = 0.03), while heterozygous patients had an intermediate (but non-significant) risk (HR = 1.31, 95% CI: 0.90-1.92, p = 0.16).

Conclusion: Our results suggest that NFKB1-94ATTG ins/del polymorphism is associated with CV disease in patients with RA.

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