The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2012 Jun 29

PMID 22741061

Citations 11

Authors

Maurizio Brigotti

Affiliations

Soon will be listed here.

Abstract

Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that recognizes molecular patterns common to foreign molecules through specific receptors expressed on the surface of the main actors of innate immunity, namely monocytes and neutrophils. The interactions between these toxins and neutrophils have been widely described and have stimulated intense debate. This paper is aimed at reviewing the topic, focusing particularly on implications for the pathogenesis and diagnosis of hemolytic uremic syndrome.

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