A Common Strategy for Host RNA Degradation by Divergent Viruses

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 Jun 29

PMID 22740404

Citations 96

Authors

Marta Maria Gaglia

Sergio Covarrubias

Wesley Wong

Britt A Glaunsinger

Affiliations

Soon will be listed here.

Abstract

Infection with gammaherpesviruses, alphaherpesviruses, and betacoronaviruses can result in widespread mRNA degradation, in each case initiated predominantly by a single viral factor. Although not homologous, these factors exhibit significant mechanistic similarities. In cells, each targets translatable RNAs for cleavage and requires host Xrn1 to complete RNA degradation, although the mechanism of targeting and the position of the primary cleavage differ. Thus, multiple host shutoff factors have converged upon a common mRNA degradation pathway.

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