Posttranslational Modifications in Connexins and Pannexins

Overview

Journal J Membr Biol

Date 2012 Jun 29

PMID 22739962

Citations 56

Authors

Scott R Johnstone

Marie Billaud

Alexander W Lohman

Evan P Taddeo

Brant E Isakson

Affiliations

Soon will be listed here.

Abstract

Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function. In this review, we assess the evidence for ubiquitination, glycosylation, phosphorylation, S-nitrosylation as well as other modifications in connexins and pannexin proteins. Based on the literature, we find that posttranslational modifications are an important component of connexin and pannexin regulation.

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