Fatigue in Systemic Lupus Erythematosus

Overview

Journal Int J Clin Rheumtol

Publisher Future Medicine

Specialty Rheumatology

Date 2012 Jun 28

PMID 22737181

Citations 39

Authors

Grace E Ahn

Rosalind Ramsey-Goldman

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus is a chronic inflammatory autoimmune disease often characterized by fatigue, with significant effects on physical functioning and wellbeing. The definition, prevalence and factors associated with fatigue, including physical activity, obesity, sleep, depression, anxiety, mood, cognitive dysfunction, vitamin D deficiency/insufficiency, pain, effects of medications and comorbidities, as well as potential therapeutic options of fatigue in the systemic lupus erythematosus population are reviewed. Due to variability in the reliability and validity of various fatigue measures used in clinical studies, clinical trial data have been challenging to interpret. Further investigation into the relationships between these risk factors and fatigue, and improved measures of fatigue, may lead to an improvement in the management of this chronic inflammatory disease.

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