Quantitative Analysis of Dynamic Airway Changes After Methacholine and Salbutamol Inhalation on Xenon-enhanced Chest CT

Overview

Journal Eur Radiol

Specialty Radiology

Date 2012 Jun 28

PMID 22736190

Citations 5

Authors

Sang Joon Park

Chang Hyun Lee

Jin Mo Goo

Jong Hyo Kim

Eun-Ah Park

Jae-Woo Jung

Heung-Woo Park

Sang-Heon Cho

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate the dynamic changes in airways in response to methacholine and salbutamol inhalation and to correlate the xenon ventilation index on xenon-enhanced chest CTs in asthmatics.

Methods: Thirty-one non-smokers (6 normal, 25 asthmatics) underwent xenon-enhanced chest CT and pulmonary function tests. Images were obtained at three stages (basal state, after methacholine inhalation and after salbutamol inhalation), and the total xenon ventilation index (TXVI) as well as airway values were measured and calculated. The repeated measures ANOVA and Spearman's correlation coefficient were used for statistical analysis.

Results: TXVI in the normal group did not significantly change (P > 0.05) with methacholine and salbutamol. For asthmatics, however, the TXVI significantly decreased after methacholine inhalation and increased after salbutamol inhalation (P < 0.05). Of the airway parameters, the airway inner area (IA) significantly increased after salbutamol inhalation in all airways (P < 0.01) in asthmatics. Airway IA, wall thickness and wall area percentage did not significantly decrease after methacholine inhalation (P > 0.05). IA of the large airways was well correlated with basal TXVI, FEV(1) and FVC (P < 0.05).

Conclusions: Airway IA is the most reliable parameter for reflecting the dynamic changes after methacholine and salbutamol inhalation, and correlates well with TXVI in asthmatics on xenon-enhanced CT.

Key Points: • In asthmatics, xenon ventilation decreases after methacholine and increases after salbutamol inhalation. • Inner airway area (IA) correlates well with xenon ventilation. • IA is the most reliable parameter reflecting airway changes in drug responses.

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