Place of (18)F-FDG-PET with Computed Tomography in the Diagnostic Algorithm of Patients with Fever of Unknown Origin

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 2012 Jun 28

PMID 22735898

Citations 18

Authors

J Crouzet

V Boudousq

C Lechiche

J P Pouget

P O Kotzki

L Collombier

J P Lavigne

A Sotto

Affiliations

Soon will be listed here.

Abstract

There is evidence for the interest of (18)F-fluoro-deoxyglucose positron emission tomography with computed tomography ((18)F-FDG-PET/CT) in fever of unknown origin (FUO) clinical investigation. However, little and conflicting data exist about its place in the investigation procedure. The aim of this work was to evaluate the clinical value of (18)F-FDG-PET/CT in patients with FUO and identify patients who need early (18)F-FDG-PET/CT rather than a last-resort procedure. We performed a 2-year retrospective cohort study at the Nîmes University Hospital, France. A total of 79 patients (36 men, 43 women, mean age 54.0 ± 16.2 years) with FUO underwent (18)F-FDG-PET/CT. A final diagnosis was established in 61 (77.2 %) cases. Aetiologies of FUO were determined using (18)F-FDG-PET/CT findings in 45 (73.8 % of patients with diagnosis) cases. The sensibility and specificity value were 98 % and 87 %, respectively. The presence of adenopathy, low haemoglobin and increased C-reactive protein (CRP) were predictors of high-yield (18)F-FDG-PET/CT. (18)F-FDG-PET/CT may help to detect most causes of FUO. The predictors of high-yield (18)F-FDG-PET/CT found in this study can help identify patients likely to benefit from specific and early imaging techniques.

Citing Articles

Diagnostic efficacy and necessity of 18F-FDG PET/CT in fever of unknown origin: insights from a retrospective cohort study.

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Performance and value of F‑FDG PET/CT in patients with fever of unknown origin.

Fathala A, Benkuddah R, Almuhaideb A Biomed Rep. 2024; 21(5):169.

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The Diagnostic Yield of [F]FDG-PET/CT in a Heterogeneous In-Patient Population with Suspected Infection or Inflammation Is Comparable to Findings in Patients with Classic Fever of Unknown Origin.

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Boulu X, El Esper I, Meyer M, Duhaut P, Salle V, Schmidt J Mayo Clin Proc Innov Qual Outcomes. 2023; 7(3):178-186.

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Predictors for spontaneous resolution of classical FUO in patients undergoing PET-CT.

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PMID: 36512183 DOI: 10.1007/s11739-022-03171-x.

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