Genome Sequence of the Model Medicinal Mushroom Ganoderma Lucidum

Overview

Journal Nat Commun

Specialty Biology

Date 2012 Jun 28

PMID 22735441

Citations 209

Authors

Shilin Chen

Jiang Xu

Chang Liu

Yingjie Zhu

David R Nelson

Shiguo Zhou

Chunfang Li

Lizhi Wang

Xu Guo

Yongzhen Sun

Hongmei Luo

Ying Li

Jingyuan Song

Bernard Henrissat

Anthony Levasseur

Jun Qian

Jianqin Li

Xiang Luo

Linchun Shi

Liu He

Li Xiang

Xiaolan Xu

Yunyun Niu

Qiushi Li

Mira V Han

Haixia Yan

Jin Zhang

Haimei Chen

Aiping Lv

Zhen Wang

Mingzhu Liu

David C Schwartz

Chao Sun

Affiliations

Soon will be listed here.

Abstract

Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. Here we report its 43.3-Mb genome, encoding 16,113 predicted genes, obtained using next-generation sequencing and optical mapping approaches. The sequence analysis reveals an impressive array of genes encoding cytochrome P450s (CYPs), transporters and regulatory proteins that cooperate in secondary metabolism. The genome also encodes one of the richest sets of wood degradation enzymes among all of the sequenced basidiomycetes. In all, 24 physical CYP gene clusters are identified. Moreover, 78 CYP genes are coexpressed with lanosterol synthase, and 16 of these show high similarity to fungal CYPs that specifically hydroxylate testosterone, suggesting their possible roles in triterpenoid biosynthesis. The elucidation of the G. lucidum genome makes this organism a potential model system for the study of secondary metabolic pathways and their regulation in medicinal fungi.

Citing Articles

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