Detection of Pleural Lymph Flow Using Indocyanine Green Fluorescence Imaging in Non-small Cell Lung Cancer Surgery: a Preliminary Study

Overview

Journal Surg Today

Specialty General Surgery

Date 2012 Jun 26

PMID 22729459

Citations 20

Authors

Kazuhiro Imai

Yoshihiro Minamiya

Hajime Saito

Taku Nakagawa

Manabu Ito

Takashi Ono

Satoru Motoyama

Yusuke Sato

Hayato Konno

Jun-Ichi Ogawa

Affiliations

Soon will be listed here.

Abstract

Purpose: Lymphatic spread of lung carcinoma to the mediastinum is a key determinant of prognosis. The lymph flow often carries metastases from the pulmonary segment directly into the mediastinal lymph nodes, without passing through the hilar nodes. This phenomenon is termed as "skip metastasis." This study investigated the subpleural lymphatic flow to the mediastinum using indocyanine green (ICG) with a near-infrared fluorescence imaging system.

Methods: Seventeen patients with lung cancer were enrolled in this study. A 0.3 ml sample of solution containing the fluorescent dye ICG (5 mg/ml) was injected into subpleural sites near the primary tumor. Fluorescence imaging was used to monitor the flow of ICG-containing lymph from the injection site for 5 min. The relationship between the anatomical segment of the primary tumor and the lymphatic flow was assessed.

Results: The lymphatic vessels draining from the injection site were revealed by the bright ICG fluorescence in 14 of the patients (82.4 %). A direct lymphatic flow to the mediastinum was confirmed in 3 of those 14 (21.4 %).

Conclusions: These findings confirm the direct flow of lymph to the mediastinum without passage through the hilum pulmonis intraoperatively. These preliminary results may provide a valuable clue for further investigations of the mechanisms underlying skip metastasis.

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