Vanin-1 Pantetheinase Drives Smooth Muscle Cell Activation in Post-arterial Injury Neointimal Hyperplasia

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Jun 22

PMID 22720042

Citations 15

Authors

K Jagadeesha Dammanahalli

Stephanie Stevens

Robert Terkeltaub

Affiliations

Soon will be listed here.

Abstract

The pantetheinase vanin-1 generates cysteamine, which inhibits reduced glutathione (GSH) synthesis. Vanin-1 promotes inflammation and tissue injury partly by inducing oxidative stress, and partly by peroxisome proliferator-activated receptor gamma (PPARγ) expression. Vascular smooth muscle cells (SMCs) contribute to neointimal hyperplasia in response to injury, by multiple mechanisms including modulation of oxidative stress and PPARγ. Therefore, we tested the hypothesis that vanin-1 drives SMC activation and neointimal hyperplasia. We studied reactive oxygen species (ROS) generation and functional responses to platelet-derived growth factor (PDGF) and the pro-oxidant diamide in cultured mouse aortic SMCs, and also assessed neointima formation after carotid artery ligation in vanin-1 deficiency. Vnn1(-/-) SMCs demonstrated decreased oxidative stress, proliferation, migration, and matrix metalloproteinase 9 (MMP-9) activity in response to PDGF and/or diamide, with the effects on proliferation linked, in these studies, to both increased GSH levels and PPARγ expression. Vnn1(-/-) mice displayed markedly decreased neointima formation in response to carotid artery ligation, including decreased intima:media ratio and cross-sectional area of the neointima. We conclude that vanin-1, via dual modulation of GSH and PPARγ, critically regulates the activation of cultured SMCs and development of neointimal hyperplasia in response to carotid artery ligation. Vanin-1 is a novel potential therapeutic target for neointimal hyperplasia following revascularization.

Citing Articles

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VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing β‑cell dedifferentiation.

Qin W, Kang M, Li C, Zheng W, Guo Q Oncol Rep. 2023; 49(6).

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Vanin 1 Gene Role in Modulation of iNOS/MCP-1/TGF-β1 Signaling Pathway in Obese Diabetic Patients.

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Vanin 1: Its Physiological Function and Role in Diseases.

Bartucci R, Salvati A, Olinga P, Boersma Y Int J Mol Sci. 2019; 20(16).

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A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia.

Serrano R, Yu W, Graham R, Bryan R, Terkeltaub R PLoS One. 2019; 14(4):e0212235.

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