Cartilage Development and Degeneration: a Wnt Wnt Situation

Overview

Journal Cell Biochem Funct

Specialties Biochemistry
Cell Biology

Date 2012 Jun 21

PMID 22714865

Citations 22

Authors

Katherine Ann Staines

Vicky Elizabeth MacRae

Colin Farquharson

Affiliations

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Abstract

The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis.

Citing Articles

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Models of Osteoarthritis: Relevance and New Insights.

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