Differential Involvement of Prelimbic and Infralimbic Medial Prefrontal Cortex in Discrete Cue-induced Reinstatement of 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) Seeking in Rats

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2012 Jun 20

PMID 22710489

Citations 23

Authors

Kevin T Ball

Mylissa Slane

Affiliations

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Abstract

Rationale: The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) is a widely abused drug, particularly in adolescent and young adult populations. Although it was shown that MDMA-associated cues reinstate extinguished MDMA seeking in an animal relapse model, there is little information regarding the neural mechanisms underlying this behavior.

Objectives: Because the medial prefrontal cortex (mPFC) plays an important role in relapse to cocaine and methamphetamine seeking, we tested the effects of lidocaine inactivation of prelimbic (PL) and infralimbic (IL) subregions of mPFC on cue-induced relapse to MDMA seeking.

Methods: Rats were trained to respond for MDMA infusions (0.50 mg/kg/infusion, i.v.) paired with a discrete cue in daily 2-h sessions. Responding was reinforced contingent on a modified fixed ratio 5 schedule of reinforcement. Cue-induced reinstatement tests were conducted after responding was extinguished in the absence of MDMA and the conditioned cues. Prior to reinstatement tests, rats received bilateral microinjections of either lidocaine (100 μg/0.5 μl/side) or physiological saline (0.5 μl/side) delivered to either PL or IL mPFC.

Results: Microinjections of lidocaine into PL completely blocked reinstatement of MDMA-seeking behavior compared with saline microinjections into the same region. Lidocaine microinjections did not, however, have an effect on food-maintained responding, ruling out a nonspecific disruption of motor performance. Conversely, lidocaine inactivation of IL had no effect on reinstatement of MDMA seeking or food-maintained responding.

Conclusions: Our results provide direct support for PL activation in reinstatement of MDMA-seeking behavior. Moreover, akin to cocaine seeking, there appears to be differential involvement of PL and IL subregions in this behavior.

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References

Ball K, Budreau D, Rebec G . Context-dependent behavioural and neuronal sensitization in striatum to MDMA (ecstasy) administration in rats. Eur J Neurosci. 2006; 24(1):217-28. DOI: 10.1111/j.1460-9568.2006.04885.x. View

Ball K, Wellman C, Miller B, Rebec G . Electrophysiological and structural alterations in striatum associated with behavioral sensitization to (±)3,4-methylenedioxymethamphetamine (Ecstasy) in rats: role of drug context. Neuroscience. 2010; 171(3):794-811. PMC: 2987517. DOI: 10.1016/j.neuroscience.2010.09.041. View

Gouzoulis-Mayfrank E, Fischermann T, Rezk M, Thimm B, Hensen G, Daumann J . Memory performance in polyvalent MDMA (ecstasy) users who continue or discontinue MDMA use. Drug Alcohol Depend. 2005; 78(3):317-23. DOI: 10.1016/j.drugalcdep.2004.12.002. View

Kalivas P, Nakamura M . Neural systems for behavioral activation and reward. Curr Opin Neurobiol. 1999; 9(2):223-7. DOI: 10.1016/s0959-4388(99)80031-2. View

Geisler S, Derst C, Veh R, Zahm D . Glutamatergic afferents of the ventral tegmental area in the rat. J Neurosci. 2007; 27(21):5730-43. PMC: 3202987. DOI: 10.1523/JNEUROSCI.0012-07.2007. View

Winstock A, Griffiths P, Stewart D . Drugs and the dance music scene: a survey of current drug use patterns among a sample of dance music enthusiasts in the UK. Drug Alcohol Depend. 2001; 64(1):9-17. DOI: 10.1016/s0376-8716(00)00215-5. View

Carter B, Tiffany S . Meta-analysis of cue-reactivity in addiction research. Addiction. 1999; 94(3):327-40. View

Lasseter H, Xie X, Ramirez D, Fuchs R . Prefrontal cortical regulation of drug seeking in animal models of drug relapse. Curr Top Behav Neurosci. 2010; 3:101-17. PMC: 4381832. DOI: 10.1007/7854_2009_19. View

Sun W, Rebec G . Lidocaine inactivation of ventral subiculum attenuates cocaine-seeking behavior in rats. J Neurosci. 2003; 23(32):10258-64. PMC: 6741020. View

10.

Robinson T, Berridge K . The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev. 1993; 18(3):247-91. DOI: 10.1016/0165-0173(93)90013-p. View

11.

Topp L, Hando J, Dillon P, Roche A, Solowij N . Ecstasy use in Australia: patterns of use and associated harm. Drug Alcohol Depend. 1999; 55(1-2):105-15. DOI: 10.1016/s0376-8716(99)00002-2. View

12.

McFarland K, Lapish C, Kalivas P . Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci. 2003; 23(8):3531-7. PMC: 6742291. View

13.

Fuchs R, Evans K, Parker M, See R . Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl). 2004; 176(3-4):459-65. DOI: 10.1007/s00213-004-1895-6. View

14.

Berendse H, Galis-de Graaf Y, Groenewegen H . Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J Comp Neurol. 1992; 316(3):314-47. DOI: 10.1002/cne.903160305. View

15.

Shalev U, Grimm J, Shaham Y . Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol Rev. 2002; 54(1):1-42. DOI: 10.1124/pr.54.1.1. View

16.

Sesack S, Deutch A, Roth R, Bunney B . Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J Comp Neurol. 1989; 290(2):213-42. DOI: 10.1002/cne.902900205. View

17.

Park W, BARI A, Jey A, Anderson S, Spealman R, Rowlett J . Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J Neurosci. 2002; 22(7):2916-25. PMC: 6758324. DOI: 20026235. View

18.

Le A, Shaham Y . Neurobiology of relapse to alcohol in rats. Pharmacol Ther. 2002; 94(1-2):137-56. DOI: 10.1016/s0163-7258(02)00200-0. View

19.

Pope Jr H, Pope K . Drug use and life style among college undergraduates: a 30-year longitudinal study. Am J Psychiatry. 2001; 158(9):1519-21. DOI: 10.1176/appi.ajp.158.9.1519. View

20.

Parrott A . Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy. J Psychopharmacol. 2005; 19(1):71-83. DOI: 10.1177/0269881105048900. View