Cushing's Disease

Overview

Journal Orphanet J Rare Dis

Publisher Biomed Central

Specialty General Medicine

Date 2012 Jun 20

PMID 22710101

Citations 25

Authors

Frederic Castinetti

Isabelle Morange

Bernard Conte-Devolx

Thierry Brue

Affiliations

Soon will be listed here.

Abstract

Cushing's disease, or pituitary ACTH dependent Cushing's syndrome, is a rare disease responsible for increased morbidity and mortality. Signs and symptoms of hypercortisolism are usually non specific: obesity, signs of protein wasting, increased blood pressure, variable levels of hirsutism. Diagnosis is frequently difficult, and requires a strict algorithm. First-line treatment is based on transsphenoidal surgery, which cures 80% of ACTH-secreting microadenomas. The rate of remission is lower in macroadenomas. Other therapeutic modalities including anticortisolic drugs, radiation techniques or bilateral adrenalectomy will thus be necessary to avoid long-term risks (metabolic syndrome, osteoporosis, cardiovascular disease) of hypercortisolism. This review summarizes potential pathophysiological mechanisms, diagnostic approaches, and therapies.

Citing Articles

Pasireotide-induced hyperglycemia in Cushing's disease and Acromegaly: A clinical perspective and algorithms proposal.

Witek P, Bolanowski M, Kretowski A, Glowinska A Front Endocrinol (Lausanne). 2024; 15:1455465.

PMID: 39735646 PMC: 11672337. DOI: 10.3389/fendo.2024.1455465.

PitNETs and the gut microbiota: potential connections, future directions.

Nie D, Li C, Zhang Y Front Endocrinol (Lausanne). 2023; 14:1255911.

PMID: 38027221 PMC: 10657991. DOI: 10.3389/fendo.2023.1255911.

Glymphatic transport is reduced in rats with spontaneous pituitary tumor.

Li L, Ding G, Zhang L, Luo H, Davoodi-Bojd E, Li Q Front Med (Lausanne). 2023; 10:1189614.

PMID: 37601793 PMC: 10436560. DOI: 10.3389/fmed.2023.1189614.

Neurosurgical aspects and clinical outcomes on the treatment of Cushing disease in pediatric patients: Case series and literature review.

Castillo-Huerta N, Carassa de la Cruz J, Quispe-Garate L, Levano-Martinez M, Cabrera B, Sheen E Surg Neurol Int. 2023; 14:123.

PMID: 37151460 PMC: 10159280. DOI: 10.25259/SNI_64_2023.

Pituitary adenomas and cerebrovascular disease: A review on pathophysiology, prevalence, and treatment.

Osorio R, Oh J, Choudhary N, Lad M, Savastano L, Aghi M Front Endocrinol (Lausanne). 2022; 13:1064216.

PMID: 36578965 PMC: 9791098. DOI: 10.3389/fendo.2022.1064216.

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