Regulation of Immunity Via Multipotent Mesenchymal Stromal Cells

Overview

Journal Acta Naturae

Specialty Biology

Date 2012 Jun 19

PMID 22708060

Citations 6

Authors

Y P Rubtsov

Y G Suzdaltseva

K V Goryunov

N I Kalinina

V Y Sysoeva

V A Tkachuk

Affiliations

Soon will be listed here.

Abstract

Immune cells responsible for inflammation development are involved in tissue damage caused by wounding and various pathologies. Control of immune cell activation could be of significant benefit for regenerative medicine and the treatment of patients with autoimmune and degenerative diseases. It is a proven fact that MCSs (multipotent mesenchymal stromal cells) are capable of suppressing immune responses via the inhibition of dendritic cell maturation and via the restraining of the T, B, and NK cell function in the course of autoimmune diseases and various forms of inflammation. MSCs can be isolated easily from almost every type of tissue or organ and subsequently expandedin vitro. These cells are self-renewable and can be differentiated into various cell types of mesenchymal lineage. The current review contains a collection and critical analysis of data regarding the molecular mechanisms responsible for cross-talk between immune cells and MSCs. Some of these mechanisms can be used for the development of new practical approaches for the treatment of autoimmune diseases.

Citing Articles

Immunomodulatory functions of human mesenchymal stromal cells are enhanced when cultured on HEP/COL multilayers supplemented with interferon-gamma.

Haseli M, Castilla-Casadiego D, Pinzon-Herrera L, Hillsley A, Miranda-Munoz K, Sivaraman S Mater Today Bio. 2022; 13:100194.

PMID: 35005599 PMC: 8715375. DOI: 10.1016/j.mtbio.2021.100194.

Platelet-rich Plasma and Mesenchymal Stem Cells Local Infiltration Promote Functional Recovery and Histological Repair of Experimentally Transected Sciatic Nerves in Rats.

Kokkalas N, Kokotis P, Diamantopoulou K, Galanos A, Lelovas P, Papachristou D Cureus. 2020; 12(5):e8262.

PMID: 32596080 PMC: 7313431. DOI: 10.7759/cureus.8262.

Molecular Mechanisms of Immunomodulation Properties of Mesenchymal Stromal Cells: A New Insight into the Role of ICAM-1.

Rubtsov Y, Goryunov K, Romanov A, Suzdaltseva Y, Sharonov G, Tkachuk V Stem Cells Int. 2017; 2017:6516854.

PMID: 28761447 PMC: 5518497. DOI: 10.1155/2017/6516854.

The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M. tuberculosis infected mice.

Nenasheva T, Nikolaev A, Diykanov D, Sukhanova A, Tcyganov E, Panteleev A PLoS One. 2017; 12(6):e0178983.

PMID: 28594940 PMC: 5464766. DOI: 10.1371/journal.pone.0178983.

Bobyleva P, Andreeva E, Gornostaeva A, Buravkova L Stem Cells Int. 2016; 2016:4726267.

PMID: 26880965 PMC: 4736565. DOI: 10.1155/2016/4726267.

References

Fiorina P, Jurewicz M, Augello A, Vergani A, Dada S, La Rosa S . Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. J Immunol. 2009; 183(2):993-1004. PMC: 3895445. DOI: 10.4049/jimmunol.0900803. View

Theiss H, Vallaster M, Rischpler C, Krieg L, Zaruba M, Brunner S . Dual stem cell therapy after myocardial infarction acts specifically by enhanced homing via the SDF-1/CXCR4 axis. Stem Cell Res. 2011; 7(3):244-55. DOI: 10.1016/j.scr.2011.05.003. View

Spaggiari G, Abdelrazik H, Becchetti F, Moretta L . MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood. 2009; 113(26):6576-83. DOI: 10.1182/blood-2009-02-203943. View

Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts A . Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008; 2(2):141-50. DOI: 10.1016/j.stem.2007.11.014. View

Joo S, Cho K, Jung Y, Kim H, Park S, Choi Y . Mesenchymal stromal cells inhibit graft-versus-host disease of mice in a dose-dependent manner. Cytotherapy. 2010; 12(3):361-70. DOI: 10.3109/14653240903502712. View

Polchert D, Sobinsky J, Douglas G, Kidd M, Moadsiri A, Reina E . IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur J Immunol. 2008; 38(6):1745-55. PMC: 3021120. DOI: 10.1002/eji.200738129. View

Wynn R, Hart C, Corradi-Perini C, ONeill L, Evans C, Wraith J . A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood. 2004; 104(9):2643-5. DOI: 10.1182/blood-2004-02-0526. View

Mohty M, Ho A . In and out of the niche: perspectives in mobilization of hematopoietic stem cells. Exp Hematol. 2011; 39(7):723-9. DOI: 10.1016/j.exphem.2011.05.004. View

Westrich J, Yaeger P, He C, Stewart J, Chen R, Seleznik G . Factors affecting residence time of mesenchymal stromal cells (MSC) injected into the myocardium. Cell Transplant. 2010; 19(8):937-48. DOI: 10.3727/096368910X494911. View

10.

Raicevic G, Rouas R, Najar M, Stordeur P, Boufker H, Bron D . Inflammation modifies the pattern and the function of Toll-like receptors expressed by human mesenchymal stromal cells. Hum Immunol. 2009; 71(3):235-44. DOI: 10.1016/j.humimm.2009.12.005. View

11.

Rafei M, Hsieh J, Fortier S, Li M, Yuan S, Birman E . Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood. 2008; 112(13):4991-8. DOI: 10.1182/blood-2008-07-166892. View

12.

Zimmermann S, Voss M, Kaiser S, Kapp U, Waller C, Martens U . Lack of telomerase activity in human mesenchymal stem cells. Leukemia. 2003; 17(6):1146-9. DOI: 10.1038/sj.leu.2402962. View

13.

Burastero G, Scarfi S, Ferraris C, Fresia C, Sessarego N, Fruscione F . The association of human mesenchymal stem cells with BMP-7 improves bone regeneration of critical-size segmental bone defects in athymic rats. Bone. 2010; 47(1):117-26. DOI: 10.1016/j.bone.2010.03.023. View

14.

Zhang W, Ge W, Li C, You S, Liao L, Han Q . Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells Dev. 2004; 13(3):263-71. DOI: 10.1089/154732804323099190. View

15.

Tang J, Wang J, Zheng F, Kong X, Guo L, Yang J . Combination of chemokine and angiogenic factor genes and mesenchymal stem cells could enhance angiogenesis and improve cardiac function after acute myocardial infarction in rats. Mol Cell Biochem. 2010; 339(1-2):107-18. DOI: 10.1007/s11010-009-0374-0. View

16.

Ren G, Zhao X, Zhang L, Zhang J, LHuillier A, Ling W . Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol. 2010; 184(5):2321-8. PMC: 2881946. DOI: 10.4049/jimmunol.0902023. View

17.

Le Blanc K, Rasmusson I, Gotherstrom C, Seidel C, Sundberg B, Sundin M . Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes. Scand J Immunol. 2004; 60(3):307-15. DOI: 10.1111/j.0300-9475.2004.01483.x. View

18.

Battiwalla M, Hematti P . Mesenchymal stem cells in hematopoietic stem cell transplantation. Cytotherapy. 2009; 11(5):503-15. PMC: 2766085. DOI: 10.1080/14653240903193806. View

19.

Hoyne G . Mechanisms that regulate peripheral immune responses to control organ-specific autoimmunity. Clin Dev Immunol. 2011; 2011:294968. PMC: 3095406. DOI: 10.1155/2011/294968. View

20.

Tsai C, Chen C, Liu H, Lee Y, Wang H, Hou L . Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines. J Biomed Sci. 2010; 17:64. PMC: 2923118. DOI: 10.1186/1423-0127-17-64. View