A Histone Acetyltransferase Regulates Active DNA Demethylation in Arabidopsis

Overview

Journal Science

Specialty Science

Date 2012 Jun 16

PMID 22700931

Citations 120

Authors

Weiqiang Qian

Daisuke Miki

Heng Zhang

Yunhua Liu

Xi Zhang

Kai Tang

Yunchao Kan

Honggui La

Xiaojie Li

Shaofang Li

Xiaohong Zhu

Xiaobing Shi

Kangling Zhang

Olga Pontes

Xuemei Chen

Renyi Liu

Zhizhong Gong

Jian-Kang Zhu

Affiliations

Soon will be listed here.

Abstract

Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 and related 5-methylcytosine DNA glycosylases. IDM1 binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and acetylates H3 to create a chromatin environment permissible for 5-methylcytosine DNA glycosylases to function. Our study reveals how some genes are indicated by multiple epigenetic marks for active DNA demethylation and protection from silencing.

Citing Articles

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Transgenerational increases in DNA methylation in Arabidopsis plants defective in active DNA demethylation.

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