Neurotropic Virus Tracing Suggests a Membranous-coating-mediated Mechanism for Transsynaptic Communication

Overview

Journal J Comp Neurol

Specialty Neurology

Date 2012 Jun 16

PMID 22700307

Citations 87

Authors

Yan-Chao Li

Wan-Zhu Bai

Norio Hirano

Tsuyako Hayashida

Takahide Taniguchi

Yoichi Sugita

Koujiro Tohyama

Tsutomu Hashikawa

Affiliations

Soon will be listed here.

Abstract

Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions.

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References

Clarke J, McFerran J . An electron microscopic study of haemagglutinating encephalomyelitis virus of pigs. J Gen Virol. 1971; 13(2):339-44. DOI: 10.1099/0022-1317-13-2-339. View

Lewis P, Lentz T . Rabies virus entry into cultured rat hippocampal neurons. J Neurocytol. 1999; 27(8):559-73. DOI: 10.1023/a:1006912610044. View

Iwasaki Y, Clark H . Cell to cell transmission of virus in the central nervous system. II. Experimental rabies in mouse. Lab Invest. 1975; 33(4):391-9. View

Tooze J, Tooze S, Fuller S . Sorting of progeny coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells. J Cell Biol. 1987; 105(3):1215-26. PMC: 2114808. DOI: 10.1083/jcb.105.3.1215. View

Marchand C, Schwab M . Binding, uptake and retrograde axonal transport of herpes virus suis in sympathetic neurons. Brain Res. 1986; 383(1-2):262-70. DOI: 10.1016/0006-8993(86)90024-7. View

Hobman T . Targeting of viral glycoproteins to the Golgi complex. Trends Microbiol. 1993; 1(4):124-30. PMC: 7133355. DOI: 10.1016/0966-842x(93)90126-c. View

Meyvisch C, Hoorens J . An electron microscopic study of experimentally-induced HEV encephalitis. Vet Pathol. 1978; 15(1):102-13. DOI: 10.1177/030098587801500112. View

Superti F, Seganti L, Ruggeri F, Tinari A, Donelli G, Orsi N . Entry pathway of vesicular stomatitis virus into different host cells. J Gen Virol. 1987; 68 ( Pt 2):387-99. DOI: 10.1099/0022-1317-68-2-387. View

Dolivo M, Beretta E, BONIFAS V, FOROGLOU C . Ultrastructure and function in sympathetic ganglia isolated from rats infected with pseudorabies virus. Brain Res. 1978; 140(1):111-23. DOI: 10.1016/0006-8993(78)90241-x. View

10.

Mengeling W, Boothe A, Ritchie A . Characteristics of a coronavirus (strain 67N) of pigs. Am J Vet Res. 1972; 33(2):297-308. View

11.

GRAFSTEIN B . Transneuronal transfer of radioactivity in the central nervous system. Science. 1971; 172(3979):177-9. DOI: 10.1126/science.172.3979.177. View

12.

Chasey D, Alexander D . Morphogenesis of avian infectious bronchitis virus in primary chick kidney cells. Arch Virol. 1976; 52(1-2):101-11. PMC: 7086645. DOI: 10.1007/BF01317869. View

13.

Dal Canto M, Rabinowitz S, Johnson T . In vivo assembly and maturation of vesicular stomatitis virus. Lab Invest. 1976; 35(6):515-24. View

14.

Sun X, Yau V, Briggs B, Whittaker G . Role of clathrin-mediated endocytosis during vesicular stomatitis virus entry into host cells. Virology. 2005; 338(1):53-60. DOI: 10.1016/j.virol.2005.05.006. View

15.

Hirano N, Ono K, Takasawa H, Murakami T, Haga S . Replication and plaque formation of swine hemagglutinating encephalomyelitis virus (67N) in swine cell line, SK-K culture. J Virol Methods. 1990; 27(1):91-100. PMC: 7119732. DOI: 10.1016/0166-0934(90)90149-a. View

16.

Yagami K, Hirai K, Hirano N . Pathogenesis of haemagglutinating encephalomyelitis virus (HEV) in mice experimentally infected by different routes. J Comp Pathol. 1986; 96(6):645-57. PMC: 7130377. DOI: 10.1016/0021-9975(86)90061-7. View

17.

Salanueva I, Carrascosa J, Risco C . Structural maturation of the transmissible gastroenteritis coronavirus. J Virol. 1999; 73(10):7952-64. PMC: 112809. DOI: 10.1128/JVI.73.10.7952-7964.1999. View

18.

Charlton K, Casey G . Experimental rabies in skunks: immunofluorescence light and electron microscopic studies. Lab Invest. 1979; 41(1):36-44. View

19.

Waxman S, Waxman M, Pappas G . Coordinated micropinocytotic activity of adjacent neuronal membranes in mammalian central nervous system. Neurosci Lett. 1980; 20(2):141-6. DOI: 10.1016/0304-3940(80)90136-6. View

20.

Card J, Rinaman L, Lynn R, Lee B, Meade R, Miselis R . Pseudorabies virus infection of the rat central nervous system: ultrastructural characterization of viral replication, transport, and pathogenesis. J Neurosci. 1993; 13(6):2515-39. PMC: 6576492. View