Strategies to Decrease Ongoing Oxidant Burden in Chronic Obstructive Pulmonary Disease

Overview

Journal Expert Rev Clin Pharmacol

Specialty Pharmacology

Date 2012 Jun 16

PMID 22697592

Citations 11

Authors

Irfan Rahman

Vuokko L Kinnula

Affiliations

Soon will be listed here.

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity globally, and its development is mainly associated with tobacco/biomass smoke-induced oxidative stress. Hence, targeting systemic and local oxidative stress with agents that can balance the antioxidant/redox system can be expected to be useful in the treatment of COPD. Preclinical and clinical trials have revealed that antioxidants/redox modulators can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling and inflammatory gene expression; and are especially useful in preventing COPD exacerbations. In this review, various novel approaches and problems associated with these approaches in COPD are reviewed.

Citing Articles

The Role of Ferroptosis in Blood-Brain Barrier Injury.

Zhao Y, Liu Y, Xu Y, Li K, Zhou L, Qiao H Cell Mol Neurobiol. 2022; 43(1):223-236.

PMID: 35106665 PMC: 11415168. DOI: 10.1007/s10571-022-01197-5.

Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies.

Schiffers C, Reynaert N, Wouters E, van der Vliet A Antioxidants (Basel). 2021; 10(11).

PMID: 34829671 PMC: 8615131. DOI: 10.3390/antiox10111799.

Total Antioxidant Status in Stable Chronic Obstructive Pulmonary Disease.

Hlavati M, Tomic S, Buljan K, Buljanovic V, Feldi I, Butkovic-Soldo S Int J Chron Obstruct Pulmon Dis. 2020; 15:2411-2419.

PMID: 33116456 PMC: 7547784. DOI: 10.2147/COPD.S264944.

Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Meyer cv. Silvatica.

Qi Z, Li Z, Guan X, Wang C, Wang F, Li P Molecules. 2019; 24(6).

PMID: 30909565 PMC: 6470847. DOI: 10.3390/molecules24061159.

Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress.

Reddy A, Lakshmi S, Banno A, Reddy R Free Radic Biol Med. 2018; 126:350-357.

PMID: 30118830 PMC: 6368849. DOI: 10.1016/j.freeradbiomed.2018.08.014.

References

Buist A, McBurnie M, Vollmer W, Gillespie S, Burney P, Mannino D . International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet. 2007; 370(9589):741-50. DOI: 10.1016/S0140-6736(07)61377-4. View

Lee J, Jung H, Giang P, Jin X, Lee S, Son P . Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera. J Pharmacol Exp Ther. 2005; 316(1):271-8. DOI: 10.1124/jpet.105.092486. View

Hackett N, Heguy A, Harvey B, OConnor T, Luettich K, Flieder D . Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers. Am J Respir Cell Mol Biol. 2003; 29(3 Pt 1):331-43. DOI: 10.1165/rcmb.2002-0321OC. View

Cantin A, North S, Hubbard R, Crystal R . Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol (1985). 1987; 63(1):152-7. DOI: 10.1152/jappl.1987.63.1.152. View

Lakari E, Paakko P, Kinnula V . Manganese superoxide dismutase, but not CuZn superoxide dismutase, is highly expressed in the granulomas of pulmonary sarcoidosis and extrinsic allergic alveolitis. Am J Respir Crit Care Med. 1998; 158(2):589-96. DOI: 10.1164/ajrccm.158.2.9711059. View

Mazur W, Lindholm P, Vuorinen K, Myllarniemi M, Salmenkivi K, Kinnula V . Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia. APMIS. 2010; 118(9):703-12. DOI: 10.1111/j.1600-0463.2010.02646.x. View

Lehtonen S, Svensk A, Soini Y, Paakko P, Hirvikoski P, Kang S . Peroxiredoxins, a novel protein family in lung cancer. Int J Cancer. 2004; 111(4):514-21. DOI: 10.1002/ijc.20294. View

Rytila P, Rehn T, Ilumets H, Rouhos A, Sovijarvi A, Myllarniemi M . Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD. Respir Res. 2006; 7:69. PMC: 1524947. DOI: 10.1186/1465-9921-7-69. View

Comhair S, Lewis M, Bhathena P, Hammel J, Erzurum S . Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease. Am J Respir Crit Care Med. 1999; 159(6):1824-9. DOI: 10.1164/ajrccm.159.6.9810044. View

10.

Gilks C, Price K, Wright J, Churg A . Antioxidant gene expression in rat lung after exposure to cigarette smoke. Am J Pathol. 1998; 152(1):269-78. PMC: 1858137. View

11.

Kensler T, Wakabayashi N, Biswal S . Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2006; 47:89-116. DOI: 10.1146/annurev.pharmtox.46.120604.141046. View

12.

Rangasamy T, Guo J, Mitzner W, Roman J, Singh A, Fryer A . Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med. 2005; 202(1):47-59. PMC: 2212893. DOI: 10.1084/jem.20050538. View

13.

Soini Y, Kahlos K, Napankangas U, Kaarteenaho-Wiik R, Saily M, Koistinen P . Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma. Clin Cancer Res. 2001; 7(6):1750-7. View

14.

Holmgren A . Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal. 2001; 2(4):811-20. DOI: 10.1089/ars.2000.2.4-811. View

15.

Grillage M . Long-term oral carbocisteine therapy in patients with chronic bronchitis. A double blind trial with placebo control. Br J Clin Pract. 1985; 39(10):395-8. View

16.

Giudice A, Arra C, Turco M . Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents. Methods Mol Biol. 2010; 647:37-74. DOI: 10.1007/978-1-60761-738-9_3. View

17.

Pierrou S, Broberg P, ODonnell R, Pawlowski K, Virtala R, Lindqvist E . Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006; 175(6):577-86. DOI: 10.1164/rccm.200607-931OC. View

18.

Salvi S, Barnes P . Chronic obstructive pulmonary disease in non-smokers. Lancet. 2009; 374(9691):733-43. DOI: 10.1016/S0140-6736(09)61303-9. View

19.

Cakan G, Turkoz M, Turan T, Ahmed K, Nagatake T . S-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells. Microb Pathog. 2003; 34(6):261-5. DOI: 10.1016/s0882-4010(03)00048-2. View

20.

Mo Y, Feinstein S, Manevich Y, Zhang Q, Lu L, Ho Y . 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. FEBS Lett. 2003; 555(2):192-8. DOI: 10.1016/s0014-5793(03)01199-2. View