Strategies to Improve Regeneration of the Soft Palate Muscles After Cleft Palate Repair

Overview

Journal Tissue Eng Part B Rev

Specialties Anatomy & Histology
Biotechnology

Date 2012 Jun 16

PMID 22697475

Citations 18

Authors

Paola L Carvajal Monroy

Sander Grefte

Anne Marie Kuijpers-Jagtman

Frank A D T G Wagener

Johannes W Von den Hoff

Affiliations

Soon will be listed here.

Abstract

Children with a cleft in the soft palate have difficulties with speech, swallowing, and sucking. These patients are unable to separate the nasal from the oral cavity leading to air loss during speech. Although surgical repair ameliorates soft palate function by joining the clefted muscles of the soft palate, optimal function is often not achieved. The regeneration of muscles in the soft palate after surgery is hampered because of (1) their low intrinsic regenerative capacity, (2) the muscle properties related to clefting, and (3) the development of fibrosis. Adjuvant strategies based on tissue engineering may improve the outcome after surgery by approaching these specific issues. Therefore, this review will discuss myogenesis in the noncleft and cleft palate, the characteristics of soft palate muscles, and the process of muscle regeneration. Finally, novel therapeutic strategies based on tissue engineering to improve soft palate function after surgical repair are presented.

Citing Articles

Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis.

Janeckova E, Feng J, Guo T, Han X, Ghobadi A, Araujo-Villalba A Development. 2023; 150(5).

PMID: 36825984 PMC: 10108707. DOI: 10.1242/dev.201189.

TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.

Feng J, Han X, Yuan Y, Cho C, Janeckova E, Guo T Elife. 2022; 11.

PMID: 36542062 PMC: 9771365. DOI: 10.7554/eLife.80405.

Orofacial Cleft and Mandibular Prognathism-Human Genetics and Animal Models.

Jaruga A, Ksiazkiewicz J, Kuzniarz K, Tylzanowski P Int J Mol Sci. 2022; 23(2).

PMID: 35055138 PMC: 8779325. DOI: 10.3390/ijms23020953.

Effect of niche components on masseter satellite cell differentiation on fibrin coatings.

Lijten O, Rosero Salazar D, van Erp M, Bronkhorst E, Von den Hoff J Eur J Oral Sci. 2022; 130(2):e12849.

PMID: 35020959 PMC: 9303748. DOI: 10.1111/eos.12849.

Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury.

Rosero Salazar D, van Rheden R, van Hulzen M, Carvajal Monroy P, Wagener F, Von den Hoff J Biomolecules. 2021; 11(10).

PMID: 34680180 PMC: 8533998. DOI: 10.3390/biom11101547.

References

LINDMAN R, Paulin G, Stal P . Morphological characterization of the levator veli palatini muscle in children born with cleft palates. Cleft Palate Craniofac J. 2001; 38(5):438-48. DOI: 10.1597/1545-1569_2001_038_0438_mcotlv_2.0.co_2. View

Zammit P . All muscle satellite cells are equal, but are some more equal than others?. J Cell Sci. 2008; 121(Pt 18):2975-82. DOI: 10.1242/jcs.019661. View

Whitaker M, Quirk R, Howdle S, Shakesheff K . Growth factor release from tissue engineering scaffolds. J Pharm Pharmacol. 2001; 53(11):1427-37. DOI: 10.1211/0022357011777963. View

McPherron A, Lawler A, Lee S . Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997; 387(6628):83-90. DOI: 10.1038/387083a0. View

Oyama T, Nishimoto S, Ishii N, Hosokawa K . Soft palate mucosal adhesion as a preparation for Furlow's double-opposing Z-palatoplasty. Plast Reconstr Surg. 2006; 118(2):469-75. DOI: 10.1097/01.prs.0000227734.89481.3a. View

Ciciliot S, Schiaffino S . Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implications. Curr Pharm Des. 2010; 16(8):906-14. DOI: 10.2174/138161210790883453. View

Sampaolesi M, Torrente Y, Innocenzi A, Tonlorenzi R, DAntona G, Pellegrino M . Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts. Science. 2003; 301(5632):487-92. DOI: 10.1126/science.1082254. View

Li Y, Li J, Zhu J, Sun B, Branca M, Tang Y . Decorin gene transfer promotes muscle cell differentiation and muscle regeneration. Mol Ther. 2007; 15(9):1616-22. DOI: 10.1038/sj.mt.6300250. View

Wang P, Yu H, Tsai W . Modulation of alignment and differentiation of skeletal myoblasts by submicron ridges/grooves surface structure. Biotechnol Bioeng. 2010; 106(2):285-94. DOI: 10.1002/bit.22697. View

10.

Grefte S, Kuijpers-Jagtman A, Torensma R, Von den Hoff J . Skeletal muscle development and regeneration. Stem Cells Dev. 2007; 16(5):857-68. DOI: 10.1089/scd.2007.0058. View

11.

Takeuchi Y, Kodama Y, Matsumoto T . Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity. J Biol Chem. 1994; 269(51):32634-8. View

12.

Otto A, Collins-Hooper H, Patel K . The origin, molecular regulation and therapeutic potential of myogenic stem cell populations. J Anat. 2009; 215(5):477-97. PMC: 2780567. DOI: 10.1111/j.1469-7580.2009.01138.x. View

13.

Andreopoulos F, Persaud I . Delivery of basic fibroblast growth factor (bFGF) from photoresponsive hydrogel scaffolds. Biomaterials. 2005; 27(11):2468-76. DOI: 10.1016/j.biomaterials.2005.11.019. View

14.

Grefte S, Kuijpers-Jagtman A, Torensma R, Von den Hoff J . Skeletal muscle fibrosis: the effect of stromal-derived factor-1α-loaded collagen scaffolds. Regen Med. 2010; 5(5):737-47. DOI: 10.2217/rme.10.69. View

15.

BRAITHWAITE F, MAURICE D . The importance of the levator palati muscle in cleft palate closure. Br J Plast Surg. 1968; 21(1):60-2. DOI: 10.1016/s0007-1226(68)80087-6. View

16.

Cornelison D . Context matters: in vivo and in vitro influences on muscle satellite cell activity. J Cell Biochem. 2008; 105(3):663-9. PMC: 3577053. DOI: 10.1002/jcb.21892. View

17.

Desai T . Micro- and nanoscale structures for tissue engineering constructs. Med Eng Phys. 2001; 22(9):595-606. DOI: 10.1016/s1350-4533(00)00087-4. View

18.

Musaro A, Giacinti C, Borsellino G, Dobrowolny G, Pelosi L, Cairns L . Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proc Natl Acad Sci U S A. 2004; 101(5):1206-10. PMC: 337031. DOI: 10.1073/pnas.0303792101. View

19.

Tedesco F, Dellavalle A, Diaz-Manera J, Messina G, Cossu G . Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells. J Clin Invest. 2010; 120(1):11-9. PMC: 2798695. DOI: 10.1172/JCI40373. View

20.

Schmalbruch H, Hellhammer U . The number of satellite cells in normal human muscle. Anat Rec. 1976; 185(3):279-87. DOI: 10.1002/ar.1091850303. View