Current Paradigm of the 18-kDa Translocator Protein (TSPO) As a Molecular Target for PET Imaging in Neuroinflammation and Neurodegenerative Diseases

Overview

Journal Insights Imaging

Publisher Springer

Specialty Radiology

Date 2012 Jun 15

PMID 22696004

Citations 70

Authors

Alex Sik Chung Ching

Bertrand Kuhnast

Annelaure Damont

Dirk Roeda

Bertrand Tavitian

Frederic Dolle

Affiliations

Soon will be listed here.

Abstract

Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in many countries, requiring more innovative diagnostic and monitoring tools. TSPO expression may constitute a biomarker for brain inflammation that could be monitored by using TSPO tracers as neuroimaging agents. From medical imaging perspectives, this review focuses on the current concepts related to the TSPO, and discusses briefly on the status of its PET imaging related to neuroinflammation and neurodegenerative diseases in humans.

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