Enantioselective Synthesis of 1-aryl-tetrahydroisoquinolines Through Iridium Catalyzed Asymmetric Hydrogenation

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2012 Jun 15

PMID 22694215

Citations 6

Authors

Farouk Berhal

Zi Wu

Zhaoguo Zhang

Tahar Ayad

Virginie Ratovelomanana-Vidal

Affiliations

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Abstract

Asymmetric hydrogenation of 1-aryl-3,4-dihydroisoquinolines using the [IrCODCl](2)/(R)-3,5-diMe-Synphos catalyst is reported. Under mild reaction conditions, this atom-economical process provides easy access to a variety of enantioenriched 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives, which are important pharmacophores found in several pharmaceutical drug candidates, in high yields and enantiomeric excesses up to 99% after a single crystallization.

Citing Articles

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