Incidental Renal Cell Carcinoma Presenting in a Renal Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease: a Case Report

Overview

Journal J Med Case Rep

Publisher Biomed Central

Specialty General Medicine

Date 2012 Jun 14

PMID 22691223

Citations 2

Authors

Toshihiro Misumi

Kentaro Ide

Takashi Onoe

Masataka Banshodani

Hirofumi Tazawa

Yoshifumi Teraoka

Ryuichi Hotta

Masahiro Yamashita

Hirotaka Tashiro

Hideki Ohdan

Affiliations

Soon will be listed here.

Abstract

Introduction: We report an instructive case of incidental renal cell carcinoma in a patient with autosomal dominant polycystic kidney disease who underwent simultaneous bilateral native nephrectomy and living donor renal transplantation.

Case Presentation: A 57-year-old Asian man with end-stage kidney disease due to autosomal dominant polycystic kidney disease received a living kidney graft from his brother. Because of recurrent infection, chronic pain and enlarged kidneys, he underwent a bilateral nephrectomy with concomitant renal transplantation. The total weight of the removed kidneys was 6kg; the maximal diameter of the larger kidney was 28cm. His left kidney had a 1cm diameter tumor. Pathology indicated papillary renal cell carcinoma. At the time of this report, the transplant kidney function was normal with no evidence of local recurrence or distant metastasis.

Conclusion: This case shows and reinforces the importance of considering the possibility of an occult malignancy in the native kidneys of patients with autosomal dominant polycystic kidney disease. Simultaneous bilateral native nephrectomy should be considered in these renal transplant recipients not only for preventing the development of adverse symptoms but also for detecting an occult malignancy.

Citing Articles

Incidental occurrence of papillary renal cell carcinoma in the native kidney with autosomal dominant polycystic kidney disease after renal transplantation: A case report.

Abbas M, Patzel M, Thurn A, Brinkmann O, Bettendorf O Mol Clin Oncol. 2021; 15(5):223.

PMID: 34548922 PMC: 8447179. DOI: 10.3892/mco.2021.2386.

Sarcomatoid renal cell carcinoma with autosomal dominant polycystic kidney disease: a case report and literature review.

Hakozaki Y, Uchiyama K, Yanai A, Yamada D, Kamijo Y, Ishibashi Y CEN Case Rep. 2020; 10(2):199-207.

PMID: 33064294 PMC: 8019437. DOI: 10.1007/s13730-020-00544-z.

References

Torres V, Harris P, Pirson Y . Autosomal dominant polycystic kidney disease. Lancet. 2007; 369(9569):1287-1301. DOI: 10.1016/S0140-6736(07)60601-1. View

Ubara Y . New therapeutic option for autosomal dominant polycystic kidney disease patients with enlarged kidney and liver. Ther Apher Dial. 2006; 10(4):333-41. DOI: 10.1111/j.1744-9987.2006.00386.x. View

Bendavid Y, Moloo H, Klein L, Burpee S, Schlachta C, Poulin E . Laparoscopic nephrectomy for autosomal dominant polycystic kidney disease. Surg Endosc. 2004; 18(5):751-4. DOI: 10.1007/s00464-003-9172-z. View

Rayner B, Cassidy M, JACOBSEN J, Pascoe M, Pontin A, van Zyl Smit R . Is preliminary binephrectomy necessary in patients with autosomal dominant polycystic kidney disease undergoing renal transplantation?. Clin Nephrol. 1990; 34(3):122-4. View

Patard J, Shvarts O, Lam J, Pantuck A, Kim H, Ficarra V . Safety and efficacy of partial nephrectomy for all T1 tumors based on an international multicenter experience. J Urol. 2004; 171(6 Pt 1):2181-5, quiz 2435. DOI: 10.1097/01.ju.0000124846.37299.5e. View

Cornelis F, Couzi L, Le Bras Y, Hubrecht R, Dodre E, Genevieve M . Embolization of polycystic kidneys as an alternative to nephrectomy before renal transplantation: a pilot study. Am J Transplant. 2010; 10(10):2363-9. DOI: 10.1111/j.1600-6143.2010.03251.x. View

Kramer A, Sausville J, Haririan A, Bartlett S, Cooper M, Phelan M . Simultaneous bilateral native nephrectomy and living donor renal transplantation are successful for polycystic kidney disease: the University of Maryland experience. J Urol. 2008; 181(2):724-8. DOI: 10.1016/j.juro.2008.10.008. View

Tabibi A, Simforoosh N, Abadpour P, Gholamrezaie H, Nafar M . Concomitant nephrectomy of massively enlarged kidneys and renal transplantation in autosomal dominant polycystic kidney disease. Transplant Proc. 2005; 37(7):2939-40. DOI: 10.1016/j.transproceed.2005.07.053. View

Mihara S, Kuroda K, Yoshioka R, KOYAMA W . Early detection of renal cell carcinoma by ultrasonographic screening--based on the results of 13 years screening in Japan. Ultrasound Med Biol. 1999; 25(7):1033-9. DOI: 10.1016/s0301-5629(99)00070-8. View

10.

Nunes P, Mota A, Alves R, Figueiredo A, Parada B, Macario F . Simultaneous renal transplantation and native nephrectomy in patients with autosomal-dominant polycystic kidney disease. Transplant Proc. 2007; 39(8):2483-5. DOI: 10.1016/j.transproceed.2007.07.035. View

11.

Parfrey P, Bear J, Morgan J, Cramer B, McManamon P, GAULT M . The diagnosis and prognosis of autosomal dominant polycystic kidney disease. N Engl J Med. 1990; 323(16):1085-90. DOI: 10.1056/NEJM199010183231601. View

12.

Keith D, Torres V, King B, Zincki H, Farrow G . Renal cell carcinoma in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 1994; 4(9):1661-9. DOI: 10.1681/ASN.V491661. View

13.

Sulikowski T, Tejchman K, Zietek Z, Rozanski J, Domanski L, Kaminski M . Experience with autosomal dominant polycystic kidney disease in patients before and after renal transplantation: a 7-year observation. Transplant Proc. 2009; 41(1):177-80. DOI: 10.1016/j.transproceed.2008.10.034. View

14.

Thompson R, Leibovich B, Cheville J, Webster W, Lohse C, Kwon E . Is renal sinus fat invasion the same as perinephric fat invasion for pT3a renal cell carcinoma?. J Urol. 2005; 174(4 Pt 1):1218-21. DOI: 10.1097/01.ju.0000173942.19990.40. View

15.

Rozanski J, Kozlowska I, Myslak M, Domanski L, Sienko J, Ciechanowski K . Pretransplant nephrectomy in patients with autosomal dominant polycystic kidney disease. Transplant Proc. 2005; 37(2):666-8. DOI: 10.1016/j.transproceed.2004.12.115. View