Low Microvascular Density at the Tumor Center is Related to the Expression of Metalloproteases and Their Inhibitors and with the Occurrence of Distant Metastasis in Breast Carcinomas

Overview

Journal Int J Clin Oncol

Specialty Oncology

Date 2012 Jun 13

PMID 22688161

Citations 7

Authors

Oscar Fernandez-Guinea

Almudena Alvarez-Cofino

Noemi Eiro

Luis O Gonzalez

Jose M del Casar

Belen Fernandez-Garcia

Maria L Lamelas

Alejandro Andicoechea

Francisco J Vizoso

Affiliations

Soon will be listed here.

Abstract

Background: The aims of this study were to evaluate the microvascular density (MVD) at the center of breast carcinomas, its relationship with the expression of metalloproteases (MMPs) and their inhibitors (TIMPs), and its connection with the distant metastasis rate.

Methods: An immunohistochemical study of four MMPs and two TIMPs was performed on cancer specimens from 97 women with a histological confirmed diagnosis of early invasive breast cancer.

Results: Expressions of MMP-9 by cancerous cells, or MMP-11 and TIMP-2 by stromal cells, were all negative and significantly associated with MVD, whereas MMP-7 score values were positive and also significantly associated with MVD. However, positive expression of MMP-1 by mononuclear inflammatory cells was significantly associated with MVD. Multivariate analysis demonstrated a significant and inverse relationship between MVD and the occurrence of distant metastasis.

Conclusions: Our data point out the clinical importance of low MVD at the tumor center as an independent prognostic factor of distant metastasis development in breast cancer.

Citing Articles

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US-guided Diffuse Optical Tomography: Clinicopathological Features Affect Total Hemoglobin Concentration in Breast Cancer.

Zhi W, Wang Y, Chang C, Wang F, Chen Y, Hu N Transl Oncol. 2018; 11(4):845-851.

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Computational Model for Tumor Oxygenation Applied to Clinical Data on Breast Tumor Hemoglobin Concentrations Suggests Vascular Dilatation and Compression.

Welter M, Fredrich T, Rinneberg H, Rieger H PLoS One. 2016; 11(8):e0161267.

PMID: 27547939 PMC: 4993476. DOI: 10.1371/journal.pone.0161267.

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