White Matter Microstructure Alterations in Bipolar Disorder

Overview

Journal Funct Neurol

Specialties Neurology
Psychology

Date 2012 Jun 13

PMID 22687164

Citations 4

Authors

Marcella Bellani

Cinzia Perlini

Adele Ferro

Stefania Cerruti

Gianluca Rambaldelli

Miriam Isola

Roberto Cerini

Nicola Dusi

Nicola Andreone

Matteo Balestrieri

Roberto Pozzi Mucelli

Michele Tansella

Paolo Brambilla

Affiliations

Soon will be listed here.

Abstract

Genetic, neuropathological and magnetic resonance imaging findings support the presence of diffuse white matter cytoarchitectural disruption in bipolar disorder. In this study, diffusion-weighted imaging (DWI) was applied to study cortical white matter microstructure organisation in 24 patients with DSM-IV bipolar disorder and 35 matched normal controls. DWI images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined over regions of interest placed, bilaterally, in the frontal, temporal, parietal, and occipital white matter. Significantly increased ADC values were found in bipolar patients with respect to normal controls in the right temporal lobe, left parietal lobe and bilateral occipital lobes. ADC values did not associate significantly with age or with clinical variables (p>0.05). Diffuse cortical white matter alterations on DWI in bipolar disorder denote widespread disruption of white matter integrity and may be due to altered myelination and/or axonal integrity.

Citing Articles

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Bellani M, Zanette G, Zovetti N, Barillari M, Del Piccolo L, Brambilla P Front Psychiatry. 2020; 11:79.

PMID: 32174853 PMC: 7054482. DOI: 10.3389/fpsyt.2020.00079.

Squarcina L, Bellani M, Rossetti M, Perlini C, Delvecchio G, Dusi N PLoS One. 2017; 12(6):e0178089.

PMID: 28658249 PMC: 5489157. DOI: 10.1371/journal.pone.0178089.

DTI and Myelin Plasticity in Bipolar Disorder: Integrating Neuroimaging and Neuropathological Findings.

Bellani M, Boschello F, Delvecchio G, Dusi N, Altamura C, Ruggeri M Front Psychiatry. 2016; 7:21.

PMID: 26973545 PMC: 4771723. DOI: 10.3389/fpsyt.2016.00021.

Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis.

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